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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 51854 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Alemzadeh, Iran
- Abstract:
- Most natural folate derivatives are highly sensitive to temperature, oxygen and light and their stability depends on food process condition. Alginate and pectin were evaluated for folic acid encapsulation and increasing its stability. By combining them and optimising encapsulation condition the efficiency was enhanced up to 90% . Furthermore, using polymers in combined form caused decrease in folic acid leakage from capsules in acidic condition of stomach. First of all, the time of encapsulation was measured which was 140-180 minutes. In this study the effect of Calcium Chloride concentration on encapsulation was studied. Therefore, two variables were selected which were pectin to algine ratio and the CACL2 concentration which were respectively 0-0.66 and 0.5-1 molar. Finally, the suggested model by the program was the ratio of 0.326 for pectin to alginate and 1M for the concentration of CACL2 . After that drug release experiments were done in simulated instestinal condition with pH=8.2 and drug leakage tests were done in stomach condition of pH=1.2 . The results show that about 80% of the drug was released in the first hour of placing microcapsules in intestinal condition. Besides, after about 4 hours 90% of the drug was released. The release rate was almost the same between microcapsules of different polymer ratio. What’s more, the amount of leackage in acidic condition was 0.76-5.68%. The maximum was for A60:P40 and the minimum was for A70:P30. Although sphericity and morphology are importants factors , encapsulation efficinecy and stability of capsules in acidic condition are of a higher priority. A100:P0 were morphologically better than A70:P30. However, A70:P30 microcapsules play a better role both in efficiency and stability in acidic condition. Furthermore, FTIR test were done on pure ingrediensts of microcasules and also microcapsules themselves. The results show that the intensity and the extent of hydrogenic bonds are reinforced in micprocapsules
- Keywords:
- Microcapsulation ; Alginate ; Pectin ; Folic Acid (FA) ; Drug Release ; Capsulation
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