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Design and Fabrication of Mineral-based Porous Microcarrier for Bone Tissue Regeneration

Haji Abbas, Mohammad Ali | 2020

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 53674 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Mashayekhan, Shohreh; Bahrevari, Mohammad Reza
  7. Abstract:
  8. Currently, using biocompatible and injectable polymeric microcarriers as one of the efficient methods to transfer cells and active agents has gained much attention for bone regenerative medicine. However, they have some drawbacks such as weak mechanical stability and lack of mineral materials, which are the major ingredients of the bone tissues. Accordingly, it is expected that mimicking the chemical and physical structure of bone tissues could be valuable in their medical applications. Herein, a new porous biodegradable microcarriers (MCs) made of silk fibroin-oxidized alginate-bioactive glass was fabricated by electrospraying method. Response surface methodology (RSM) was used to study the quantitative influence of process parameters, including blend ratio, voltage, and syringe pump flow rate on MCs diameter, porosity and density and the optimized condition for MCs fabrication was proposed. Scanning electron microscopy (SEM) analysis revealed that the prepared MCs have a spherical shape with the size of 466 m showing a highly porous structure. Incorporation of bioactive glass in the MCs ingredients provided suitable bioactivity for osteogenesis application. Such porous MCs may be considered as promising injectable cell carriers for bone tissue engineering application
  9. Keywords:
  10. Microcarrier ; Bone Tissue Engineering ; Silk Fibroin ; Bioactive Glass ; Oxidized Alginate ; Biocompatible Polymer

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