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Synthesis and characterization of a new thermosensitive chitosan-PEG diblock copolymer

Ganji, F ; Sharif University of Technology | 2008

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  1. Type of Document: Article
  2. DOI: 10.1016/j.carbpol.2008.03.017
  3. Publisher: 2008
  4. Abstract:
  5. A novel thermosensitive hydrogel was synthesized by block copolymerization of monomethoxy poly(ethylene glycol) macromere (PEG) onto chitosan backbone, using potassium per sulfate as a free radical initiator. This block copolymer exhibits a thermoreversible transition from an injectable solution at low temperature to a gel at body temperature. Synthesized copolymers were characterized using FT-IR, 1H NMR, 13C NMR, and DSC techniques. Solubility test was performed to compare water and organo-solubility of chitosan before and after copolymerization. Sol-gel transition behavior was investigated using the vial inversion method and viscosity measurements. The gelation behavior makes the chitosan-PEG block copolymers more promising and attractive materials for biomedical applications. © 2008 Elsevier Ltd. All rights reserved
  6. Keywords:
  7. Block copolymers ; Chitin ; Chitosan ; Colloids ; Copolymerization ; Ethylene ; Ethylene glycol ; Free radicals ; Gelation ; Glycols ; Hydrogels ; Plastic products ; Polyethylene glycols ; Polymers ; Potassium ; Sulfate minerals ; Block co-polymerization ; Block copolymer ; Body temperatures ; Diblock co-polymer ; Hydrogel ; Low temperature ; Polyethylene glycol ; Synthesis and characterization ; Thermosensitive ; Amines
  8. Source: Carbohydrate Polymers ; Volume 74, Issue 3 , 2008 , Pages 435-441 ; 01448617 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0144861708001537#!