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Over-Expression of immune-related lncrnas in inflammatory demyelinating polyradiculoneuropathies

Sadeghpour, S ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.1007/s12031-020-01721-6
  3. Publisher: Humana Press Inc , 2021
  4. Abstract:
  5. Long non-coding RNAs (lncRNAs) have crucial roles in the pathogenesis of immune-related disorders. However, their role in the pathobiology of inflammatory demyelinating polyradiculoneuropathies remains unclear. In the current study, we measured peripheral expression of four lncRNAs, namely TUG1, FAS-AS1, NEAT1, and GAS5, in patients with acute/chronic inflammatory demyelinating polyradiculoneuropathies (AIDP/CIDP) compared with healthy subjects. Notably, all lncRNAs were over-expressed in patients compared with controls (P < 0.0001 for all lncRNAs). When assessing their expressions in AIDP and CIDP groups separately, TUG1 and NEAT1 were up-regulated in both patient groups compared with controls, yet FAS-AS1 and GAS5 were only up-regulated in CIDP cases. There were remarkable pairwise correlations between expression levels of these lncRNAs in all study groups. Based on the above-mentioned data, we suggest participation of these for lncRNAs in the pathogenesis of inflammatory demyelinating polyradiculoneuropathies. Moreover, FAS-AS1 and GAS5 lncRNAs have type-specific roles in this regard. Future functional studies are needed to elaborate the molecular mechanisms of the contribution of these transcripts in AIDP/CIDP. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
  6. Keywords:
  7. Complementary DNA ; Growth arrest transcript 5 ; Long untranslated RNA ; Protein ; Unclassified drug ; GAS5 long non-coding RNA, human ; Long noncoding RNA Fas-AS1, human ; NEAT1 long non-coding RNA, human ; TUG1 long noncoding RNA, human ; 10 fold cross validation ; Acute inflammatory demyelinating polyneuropathy ; Adult ; Aged ; Bayesian generalized linear model ; Chronic inflammatory demyelinating polyneuropathy ; Controlled study ; Cross validation ; Discriminant analysis ; Fas as1 gene ; Female ; Gene overexpression ; Generalized linear model ; Human ; Immune-related gene ; Machine learning ; Major clinical study ; Male ; National Institutes of Health Stroke Scale ; Neat1 gene ; Pathogenesis ; Prediction ; Sensitivity and specificity ; Tug1 gene ; Upregulation ; Genetics ; Guillain Barre syndrome ; Pathology ; Polyradiculoneuropathy ; Guillain-Barre Syndrome ; Humans ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating ; RNA, Long Noncoding ; Up-Regulation
  8. Source: Journal of Molecular Neuroscience ; Volume 71, Issue 5 , 2021 , Pages 991-998 ; 08958696 (ISSN)
  9. URL: https://link.springer.com/article/10.1007/s12031-020-01721-6