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Metal-organic frameworks-based nanomaterials for drug delivery

Saeb, M. R ; Sharif University of Technology | 2021

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  1. Type of Document: Article
  2. DOI: 10.3390/ma14133652
  3. Publisher: MDPI AG , 2021
  4. Abstract:
  5. The composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m2·g−1). Nanoscale MOFs (NMOFs), as cargo nanocarriers, have increasingly attracted the attention of scientists and biotechnologists during the past decade, in parallel with the evolution in the use of porous nanomaterials in biomedicine. Compared to other nanoparticle-based delivery systems, such as porous nanosilica, nanomicelles, and dendrimer-encapsulated nanoparticles, NMOFs are more flexible, have a higher biodegradability potential, and can be more easily functionalized to meet the required level of host–guest interactions, while preserving a larger and fully adjustable pore window in most cases. Due to these unique properties, NMOFs have the potential to carry anticancer cargos. In contrast to almost all porous materials, MOFs can be synthesized in diverse morphologies, including spherical, ellipsoidal, cubic, hexagonal, and octahedral, which facilitates the acceptance of various drugs and genes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland
  6. Keywords:
  7. Biodegradability ; Controlled drug delivery ; Nanoparticles ; Nanostructured materials ; Organometallics ; Porous materials ; Targeted drug delivery ; Delivery systems ; Dendrimer encapsulated nanoparticles ; Functionalized ; Metalorganic frameworks (MOFs) ; Nano-carriers ; Nanomicelles ; Pore windows ; Surface area ; Metal-Organic Frameworks
  8. Source: Materials ; Volume 14, Issue 13 , 2021 ; 19961944 (ISSN)
  9. URL: https://www.mdpi.com/1996-1944/14/13/3652