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The influence of the female reproductive tract and sperm features on the design of microfluidic sperm-sorting devices

Ahmadkhani, N ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1007/s10815-021-02377-w
  3. Publisher: Springer , 2022
  4. Abstract:
  5. Although medical advancements have successfully helped a lot of couples with their infertility by assisted reproductive technologies (ART), sperm selection, a crucial stage in ART, has remained challenging. Therefore, we aimed to investigate novel sperm separation methods, specifically microfluidic systems, as they do sperm selection based on sperm and/or the female reproductive tract (FRT) features without inflicting any damage to the selected sperm during the process. In this review, after an exhaustive studying of FRT features, which can implement by microfluidics devices, the focus was centered on sperm selection and investigation devices. During this study, we tried not to only point to the deficiencies of these systems, but to put forth suggestions for their improvement as well. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature
  6. Keywords:
  7. Female reproductive tract ; Infertility ; Microfluidics ; Sperm selection ; Cell separation ; Chemotaxis ; Density gradient centrifugation ; Equipment design ; Female genital system ; Fluid flow ; Hman ; Infertility therapy ; Molecular interaction ; Nonhuman ; Review ; Rheotaxis ; Sperm function ; Spermatozoon motility ; Swim up technique ; Thermotaxis ; Thigmotaxis ; Tissue structure ; Cytology ; Devices ; Microbiology ; Physiology ; Procedures ; Spermatozoon ; Adult ; Female ; Genitalia, Female ; Humans ; Male ; Reproductive Techniques, Assisted ; Sperm Count ; Spermatozoa
  8. Source: Journal of Assisted Reproduction and Genetics ; Volume 39, Issue 1 , 2022 , Pages 19-36 ; 10580468 (ISSN)
  9. URL: https://pubmed.ncbi.nlm.nih.gov/35034216