Loading...

Label-free electrochemical microfluidic biosensors: futuristic point-of-care analytical devices for monitoring diseases

Ebrahimi, G ; Sharif University of Technology | 2022

59 Viewed
  1. Type of Document: Article
  2. DOI: 10.1007/s00604-022-05316-3
  3. Publisher: Springer , 2022
  4. Abstract:
  5. The integration of microfluidics with electrochemical analysis has resulted in the development of single miniaturized detection systems, which allows the precise control of sample volume with multianalyte detection capability in a cost- and time-effective manner. Microfluidic electrochemical sensing devices (MESDs) can potentially serve as precise sensing and monitoring systems for the detection of molecular markers in various detrimental diseases. MESDs offer several advantages, including (i) automated sample preparation and detection, (ii) low sample and reagent requirement, (iii) detection of multianalyte in a single run, (iv) multiplex analysis in a single integrated device, and (v) portability with simplicity in application and disposability. Label-free MESDs can serve an affordable real-time detection with a simple analysis in a short processing time, providing point-of-care diagnosis/detection possibilities in precision medicine, and environmental analysis. In the current review, we elaborate on label-free microfluidic biosensors, provide comprehensive insights into electrochemical detection techniques, and discuss the principles of label-free microfluidic-based sensing approaches. Graphical abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature
  6. Keywords:
  7. Biosensor ; Electrochemical detection ; Label-free sensing ; Microfluidics ; Point-of-care ; Genetic procedures ; Lab on a chip ; Microfluidic analysis ; Microfluidics ; Point of care system ; Procedures ; Biosensing Techniques ; Lab-On-A-Chip Devices ; Microfluidic Analytical Techniques ; Microfluidics ; Point-of-Care Systems
  8. Source: Microchimica Acta ; Volume 189, Issue 7 , 2022 ; 00263672 (ISSN)
  9. URL: https://pubmed.ncbi.nlm.nih.gov/35687204