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Numerical Investigation of Off-axis translocation, Shape, and the Electrical Charge of a Nanoparticle in the Nanofluidic Conduit

Jodeyri, Zohreh | 2023

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 56010 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Taghipoor, Mojtaba
  7. Abstract:
  8. The advent of nanopore-based sensors based on resitive pulse sensing gave rise to a remarkable breakthrough in the detection and characterization of nanoscale species. The sensors can detect the species’concentration, size, and charge using the resistive pulse characteristics. Some strong correlations have been reported between the resitive pulse characteristics and the particle’s geometrical and physical properties. These correlations are commonly used to obtain information about the particles in commercial devices and research setups. The correlations, however, do not consider the simultaneous effect of influential factors such as particle shape, charge, and off-axis translocation, which complicates the extraction of accurate information from the resistive pulses. Here, we numerically studied the impact of the shape, charge, and position of the particles on pulse characteristics in order to estimate the errors that arise from neglecting the influence of multiple factors on resitive pulses. We consider the sphere, oblate, and prolate particles to investigate the nanoparticle shape effect. The trajectory dependency was examined by considering the translocation of nanoparticles away from the nanopore axis. Moreover, we have assumed two surface charge values to study the effect. Meanwhile, the shape and charge effect were studied for different trajectories. We observed that the simultaneous effects of influential parameters could lead to significant errors in estimating particle properties if the coupled effects are neglected. Based on the results, we introduce the “pulse waveshape” as a novel characteristic of the resitive pulse that can be utilized as a decoupling parameter in the analysis of resistive pulses
  9. Keywords:
  10. Nanosensor ; Nanoparticles ; Nanopore ; Numerical Method ; Resistive Pulse Sensing ; Resistive Pulse Characteristics ; Electric Load

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