Sharif Digital Repository

Drag reduction is one of the most important topics in aerodynamics. Several techniques have been represented to reduce this force, such as surface roughness reduction, blowing, suction, cooling the fluid, etc. Blowing and creating a film of a secondary lower viscosity fluid is the technique used here. In our computations, we used large eddy simulation approach considering viscosity ratio variations effects. Investigations were performed for multiple squared cross sectional jets inclined normally into a turbulent cross flow. Each jet generates a pair of counter rotating vortex pair (CRVP) at its downstream while entering the cross flow. Two horseshoe vortices and a couple of wake vortices... 

Fired heaters are large and complex items used in process plants. Tubular furnaces used mainly in chemical, petrochemical, and refinery process plants. For many process plants, the fired heater performance will determine process unit run-length. High tube metal temperature and coking in the process-fired heaters is one of the serious problems of process plants. Coke forms because the oil in tubes is no longer thermally stable at the operating conditions. Oil film temperature in the inside wall of tube somewhere that, process fluid has highest temperature and lowest velocity. Therefore, process fluid peak film temperature will determined rate of coke formation. This temperature is dependent... 

In recent years, it is expected that the fabrication of multilayer scaffolds and the use of different methodologies in one product can be a new progressing method in skin substitute production. Accordingly, this project aims to fabricate a bilayered composite scaffold with a combination of hydrogel and electrospinning method. We have tried to prepare a scaffold made of oxidized alginate (OAL), gelatin (G), and silk fibroin (SF) without using corrosive solvents and toxic crosslinking agents as a scaffold and drug delivery system. As different biological, chemical, physical, and mechanical factors play a vital role in the healing process, we have characterized the proposed scaffold via DSC,... 

Any factor that causes an additional pressure drop to the reservoir is called damage. Damages due to drilling, well completion and production can cause additional pressure drop to formation. In this study, damage caused by mechanical damage, well deviation from vertical (angled well), partially completed well and horizontal well and formation damage behavior during the occurrence of water and gas coning phenomenon have been investigated by simulation and the results have been verified with the analytical models available for calculating the formation skin factor. Also, by studying and examining the data and the results obtained from the simulation of the horizontal well skin factor in a data... 

Skin cancer is a common type of cancer in the world. Melanoma is considered as the deadliest form of human skin cancer that causes approximately 75% of deaths associated with this cancer. However, melanoma is curable if diagnosed in an early stage. Due to high visual similarities and diverse characteristics of lesions, it is a challenging task to differentiate between different types of skin lesions. Therefore, it is worthwhile to develop a reliable automatic system increasing the accuracy and efficiency of pathologists. Here, we propose sparse representation and dictionary learning based methods for skin lesion segmentation and classification. First, we review the steps of a computer aided... 

Skin tissue as the first protective barrier to the body is always exposed to the most injuries. The purpose of this project is to design an optimum skin scaffold capable of drug delivery for skin wounds healing. To this end, the skin scaffold has been considered as a combination of a hydrogel structure containing polymer microspheres carrying growth factor. Polyvinyl alcohol and sodium alginate polymers were utilized to make the hydrogel substrate. The hydrogel structure was optimized from the viewpoint of the percentage of gelation, water absorption, porosity, mechanical properties, biodegradability, biocompatibility and considering the volume percent of utilized polymers and the... 

Wound healing is a complex and regular process. It makes more challenge when the volume of wound exudate becomes uncontrollable. To solve this problem, hydrofiber wound dressings which contain carboxymethyl cellulose fibers are being used. Fast absorption and keeping the moisture in balance specially in chronic wounds, is one of the major features of hydrofiber wound dressings. In this research, which was conducted with the aim of investigating the synergy effect of active glasses and Hydrofiber commercial wound dressing for the healing of skin wounds, especially chronic wounds, the sol-gel method has been used to synthesize bioactive glasses based on borosilicate, replacing a part of CaO... 

The goal of the research presented in this thesis is assessment of millimeter-wave (mm-wave) reflectometry as a potential method for non-invasive detection of skin cancers. The reasons for choosing mm-waves are lower penetration, higher resolution and technology maturity. The main work of this research is numerical simulation of reflection from skin and other media as well as reflection measurement of some skin-equivalent phantoms at mm-wave frequencies. By exposing the skin to mm-waves and studying the characteristics of the reflected wave malignant lesions are differentiated from benign and normal skin tissues. Since Oxygen molecules have strong attenuation peaks around 60 GHz band, this... 

Progress aerodynamic and structural applications has lead to solid-fluid interaction (SFI) engineering. One major application of SFI is to improve of aerodynamic characteristics of airplanes. One option is to use elastic shells.this field of study is so novel and a challenge for future researches. This what current thesis is focused on We use numerical simulation in both fluid and solid parts.In other word, we employ the finite –element method to solve the solid mechanics governing equation and the finite volume element method to treat the fluid dynamics governing equations. The fluid governing equations are 2D navier- stokes equations and the solid part is the 1D Euler – Bernoulli equations... 

Transdermal drug delivery systems are products which are known to have ability to pass drugs through the skin and into the blood, so medicine effects appear as a result. During the past two decades, many scientists interested in drug delivery through the skin. Constant blood plasma level and avoiding first-pass metabolism are advantages of this system compared to oral and intravenous systems. The biggest problem in the development of these systems, is impermeability of Stratum corneum, the outermost layer of the epidermis. In this study, design and evaluation of in vitro transdermal drug delivery system for granisetron serve as treatment of nausea and vomiting was performed. For this... 

The main goal of this project is to fabricate the scaffolds including Polycaprolactone and Polyvinyle alcohol nanofibers in order to use as artificial skin. For this purpose, electrospinning parameters have been optimized for various injection rates and the scaffolds containing different percent of PCL and PVA have been made. By investigating the cell growth on these scaffolds, the one made up PVA/PCL (30% ) has been introduced as the best scaffold. To improve biological properties of chosen scaffold, a layer of collagen was coated. The angiogenesis capacity has been improved by adding Heparin to PVA nanofibers. Based on assay of heparin release, it was shown that Heparin is released within... 

Skin, as the largest organ of the body and the first protector against external injuries, plays an important role in maintaining human health. Therefore, providing a method for complete treatment of skin lesions is very important. In the last century, tissue engineering approaches, with the introduction of skin scaffolds, have been instrumental in the process of skin tissue regeneration and treatment. The aim of the present study is to construct an optimal bilayer scaffold to mimic the two outer layer of the skin (epidermis and dermis). Besides, the effects of placenta extract on acceleration of wound healing was investigated by an in-vivo test. both layer of scaffold are porous hydrogels,... 

Tissue engineering has the potential to revolutionize our health care system. Conceptually, lost or malfunctioning tissues will be replaced by man-made biological substitutes to restore, maintain, or improve function. Tissue engineering has already shown great promise to contribute to treatments of a myriad of diseases including osteoarthritis, cancer, diabetes, skin burns, cardiovascular conditions and various traumatic injuries. Tissue engineering is a highly multidisciplinary discipline that demands integration of knowledge, tools and skills from biology, chemistry, engineering and medicine. Integrating nano- and microtechnologies into clinically sized implants represents a major... 

Wound healing by engineered scaffolds is a new step in bio-technology and medical studies in recent years. The goal of the current study is to propose a novel structure for a tissue-engineered scaffold to be used in wound healing. Influenced from the multi-layered structure of natural human skin, the fabricated scaffold consists of two layers to maximize similarity with natural skin. This product is comprised of an electrospun layer made of polycaprolactone and polyvinyl alcohol and a hydrogel layer made of chitosan and gelatin. In order to form a porous medium in the hydrogel layer, freeze-gelation was used instead of freeze drying. The evaluation of fabricated scaffolds was performed by... 

Biocompatible porous polymeric scaffolds provide a suitable 3-D environment for proliferation of stem cells in human body. For instance, growth and proliferation concurrent with differentiation of stem cells in such scaffolds can regenerate the tissues or organs. In this attitude we fabricated a porous Gelatin-based scaffold using both of freeze-drying and freeze-extraction methods.Also, effect fo gamma irradiation on microstructure of scaffolds was investigated. In addition, poly(ethylene glycol) was employed to make the scaffold softer. Moreover, effects of various parameters including freezing temperature, cross-linking agent concentration, gelatin and PEG concentrations and their... 

Making artificial skin and skin alternatives is one of the most important areas in tissue engineering. Although much progress has been made so far, there is still no definitive cure for second- and third-degree burns. To create new tissue in the body, a suitable substrate for cells is needed, which is called scaffolding, and an ideal scaffold in tissue engineering should mimic the dimensions of extracellular matrix, and nanofibers seem to be the best option for this purpose. Among the methods of manufacturing of nanofibers, electrospun is very easy and accurate method. In previous studies, many natural and synthetic polymers such as chitosan, alginate, collagen, polyathylene oxide, etc.... 

Innovations in laser, microwaves, and similar technologies have significantly advanced thermal treatments for diseases or even injuries concerning skin tissue. For a thorough understanding in the underlying mechanisms of bioheat transfer behavior of skin,a1D unsteady non-dimensional hyperbolic model of heat transfer through this tissue with metabolic heat generation which is subject to specific boundary conditions, is solved numerically using the finite difference method. A thermal shock is generated at the base of the tissue, which moves forward with a finite speed. A Numerical solution for a simple one-layer skin tissue is obtained. Then, the effects of various parameters, time step,... 

As the first barrier in front of external damages, skin is prone to the largest number of damages applied to one’s body. Acute wounds are considerably prevalent world-widely, imposing very high costs to governments. The purpose of the current project, is to propose a novel skin scaffold capable of growth factor delivery for enhancing the wound healing process in acute wounds. Such a scaffold should be able to decrease the required time for healing process, also to improve the quality of the regenerated skin compared to available commercial products. Furthermore, it should be highly biocompatible, biodegradable, and non-toxic. In this project, to manufacture the artificial skin scaffold, a... 

Skin as the largest organ of the body is constructed of three distinctive layers referred to as epidermis, dermis, and hypodermis. Epidermis is the outermost layer of the skin and acts as body’s first barrier against infectious agents and contains mostly sweat glands. Dermis is the mid-layer of the skin which makes up to 70% of the skin and plays a significant role in maintaining body’s metabolism and is home to a huge part of skin’s vascular network, nerve cells and hair follicles. Hypodermis on other hand, is the deepest layer of the skin and mainly acts as a bonding layer between upper skin layers and the soft tissue underneath. Although skin is proved to have a profound ability to... 

In recent years, there has been a growing research interest in segmenting skin regions in color images. Skin segmentation aims at locating skin regions in an unconstrained input image. Skin detection is considered as an important preprocess in many applications such as face detection, face tracking, and filtering of objectionable web images. The most attractive properties of skin detection include low computational cost, increase of the total processing speed, and being invariance against rotation, scale, partial occlusion, and pose change. Because of the diversity of various image processing tasks, there exists no optimum method that can perform properly for all applications. Most of the...