Sharif Digital Repository

Bones adapt their form and structure to make an efficient use of their mass against the applied mechanical loads. So, it is not surprising to assume that the geometry and density distribution of a bone contains information about its loading history. The objective of this work was to develop a framework to simulate the bone remodeling procedure as a topology optimization process and then use this framework to develop a simple technique for estimating the dominant joint loads based on the bone’s density distribution.
At first, the remodeling equation was derived from the structural optimization task of minimizing the strain energy in each time step, using the level set method. Employment... 

Magnesium and its alloys are potentialy biodegradable implant materials due to their attractive biological properties. But their poor corrosion resistance may result in sudden failure of the implants. Recently, many researchers have focused on applications of fluorine-doped hydroxyapatiteCa10(PO4)6(OH)2−xFx (FHA, x is the degree of fluoridation) as a bioactive coating to provide early stability and long-term performance. In comparison with pure HA coating,FHA coating could provide significant dissolution-resistant property, better apatite-like layer deposition, better protein adsorption, better cell attachment and improved alkaline phosphatase activity in cell culture. In this... 

During femur fracture reduction surgery, both patients and surgeons are exposed to a great amount of radiation, which is harmful to their health. Computer-assisted orthopaedic surgery (CAOS) is a less invasive approach for its ability to reduce the usage of image intensifiers. Various robots have been developed for femur fracture reduction surgery. Most of these robots are based on serial architectures. Both low load-carrying capacity and poor accuracy are inherent to serial robots, which makes them inappropriate for femur fracture reduction. Some parallel robots using the “Stewart platform” have also been developed for femur fracture reduction, but their restricted workspace limits their... 

Since ancient time, healing patients suffering from bone deformities has been one of the most important challenges of physicians. In recent decades, by helping bio mechanic engineers external fixators has been used for this purpose. These fixators divided to parallel and series forms. One of the remarkable merit of parallel external fixators is their high maneuverability. These fixators usually have six degree of freedom, and follow the movement’s pattern of Stewart robots. In this project by studying different fixators which has been commercials, we present two conceptual models of these fixators which three and four legs are used for connecting the lower and upper plates, respectively. The... 

Treatment of critical-size bone defects caused by sport injuries, accidents, trauma, infection, and osteoporosis remains a major clinical challenge. In order to repair or regenerate large bone defects, bioactive three-dimensional scaffolds play a key role due to their multilevel porous structure, high surface area, enhanced mass transport and diffusion. Many studies reported that macropore diameters greater than 500 µm can lead to vascularized bone tissue. In this study, a hierarchically porous composite scaffold was prepared. Hierarchically porous silk fibroin- bioactive glass composite and fibroin scaffold were fabricated with controlled architecture and interconnected structure with... 

With the increase in the average age of the world's population, osteoporosis is a worldwide incidence. This disease, along with natural disasters, are important factors in the occurrence of fractures in various bones of the body. One of the methods for solving this problem and replacing with broken body bones is the use of metal implants with hydroxyapatite-based coatings. One of the common problems with using implants in the body is the infection in the adjacent parts of the implant. To overcome this problem, several studies have been carried out on the use of hydroxyapatite coatings with metal ions or antibacterial oxide compounds. In the present study, the influence of factors such as the... 

Fractures of the shaft of the long bones-especially in femur and tibia- is one of the most common fractures. In past decades various methods have been suggested for induction, fixation and repair of these fractures. The main fixation method for shaft fractures of femur and tibia in adult patients is named “Intramedullary Nailing”. In this method, after inducing the fracture, the bone marrow is pulled out via a hole created in the proximal part of the bone. Then, a nail will go down through this empty space inside the bone. This nail will be fixed in to proximal and distal parts of fractures with some locking screws. This way, the part of fracture cannot move respect to each other and the... 

The goal of fracture reduction in orthopedic surgery is to reposition the bone fragments in their anatomical orientation (alignment), and the fracture ends closed to each other (apposition). Reduction of long bone fractures is became an interesting subject in the field of robotic aided surgery in pervious decade. Nowadays reduction of femur is carried out by surgeons and medical staff in surgery. Due to the large holding forces necessary, exact positioning is difficult and time consuming. What is needed is an automated system whereby the fractured ends of the bone may be precisely positioned without the need for multiple docking attempts. The fragments need to be held in place as long as... 

Bone is one of the most vital parts of the body for almost any functional movement. Due to its many involved diseases, traumas and injuries, bone maintenance and regeneration are of high importance. Engineering and design of complex tissues, with impeccable mimicry of the native ones, are always accounted as the solution to dysfunction of body organs due to aging, various diseases, etc. However, the inability to complete mimicry of the native tissue architecture and cell microenvironment are the main barriers to functional tissue regeneration. In this project, in order to design a suitable scaffold for bone regeneration, hydrogel nanocomposites with polysaccharide basis were developed by...