Sharif Digital Repository

Designing meta-materials and cellular solids with biomimetic structures has received increasing attention in the past few years partially due to advances in additive manufacturing techniques that have enabled the fabrication of advanced materials with arbitrarily complex microarchitectures and novel functionalities. To impact on this trend, it is essential to develop our understanding about the role of microstructure on mechanical responses of these structures. Although a large literature exists on the general subject, the role of microstructure on the post-yield instability is not yet adequately documented. This research introduces a numerical approach to study the post-yield instability in... 

Abstract: In this study, chitosan–Laponite nanocomposite coatings with bone regenerative potential and controlled drug-release capacity are prepared by electrophoretic deposition technique. The controlled release of a glycopeptide drug, i.e. vancomycin, is attained by the intercalation of the polymer and drug macromolecules into silicate galleries. Fourier-transform infrared spectrometry reveals electrostatic interactions between the charged structure of clay and the amine and hydroxyl groups of chitosan and vancomycin, leading to a complex positively-charged system with high electrophoretic mobility. By applying electric field the charged particles are deposited on the surface of titanium... 

Metal-organic framework (MOF) based graphene oxide (GO) recently merits of attention because of the relative correspondence of GO with metal ions and organic binding linkers. Furthermore, introducing the GO to the Co-MOF to make a new nanoporous hybrid have are improved the selectivity and stability of the Co-MOF. Here the graphene oxide/cobalt metal organic framework (GO/Co-MOF) was synthesized by a solvothermal process using cobalt salt and terephthalic acid and used for biocidal activity, against the growth of the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria. X-ray diffraction, Fourier transform infrared spectroscopy and Raman spectroscopy were confirmed... 

Photovoltaic (PV) arrays are composed of PV cells which have a nonlinear power-voltage characteristic. To extract maximum amount of energy from a PV array, it is essential to track maximum power point (MPP). When all PV cells are subject to the same solar energy, MPP is found easily. However, in some ambient conditions, PV cells are partially or completely shadowed. Under partial shading conditions (PSCs), overall power-voltage curve will have several peaks. This paper presents a novel approach for MPP tracking, utilizing configuration of PV cells in series and parallel that may deliver maximum power in shading conditions. As such, instead of blindly searching for the global MPP among local... 

To help overcome limits to the density of conventional SRAMs and leakage current of SRAM cell in nanoscaled CMOS technology, we have developed a four-transistor SRAM cell. The newly developed CMOS four-transistor SRAM cell uses one word-line and one bit-line during read/write operation. This cell retains its data with leakage current and positive feedback without refresh cycle. The new cell size is 19% smaller than a conventional six-transistor cell using same design rules. Also the leakage current of new cell is 60% smaller than a conventional sixtransistor SRAM cell. Simulation result in 65nm CMOS technology shows new cell has correct operation during read/write operation and idle mode  

Acute lymphoblastic leukemia is one of the most common hematologic malignancies among children, caused by uncontrolled growth of leukocytes. Since the main hallmarks of the disease is not specific, a considerable number of patients have been being misdiagnosed. Early diagnosis of the disease is usually made by morphological investigation of leukocytes under microscope. In light of the facts that decrease in cytoplasm-to-nucleus ratio is one of the main indicators of cancerous cells, and an accurate segmentation phase will lead to extraction of representative features, segmentation step is acknowledged as being crucial in design of a computer aided diagnosis (CAD). Previous researches have... 

Droplet-based microfluidics offers significant advantages, such as high throughput and scalability, making platforms based on this technology ideal candidates for point-of-care (POC) testing and clinical diagnosis. However, the efficiency of co-encapsulation in droplets is suboptimal, limiting the applicability of such platforms for the biosensing applications. The homogeneity of the bioanalytes in the droplets is an unsolved problem. While there is extensive literature on the experimental setups and active methods used to increase the efficiency of such platforms, passive techniques have received less attention, and their fundamentals have not been fully explored. Here, we develop a novel... 

Cascaded split-source inverter (CSSI) is a new single-stage modular multilevel topology. Each cell of this converter converts DC to AC power in the buck or boost operation mode without any additional power switch. This paper develops a design method based on a detailed model for CSSI. This model shows that energy storage elements experience double-fundamental frequency ripples besides high-frequency ones. It accurately calculates voltage gains and capacitor voltage and inductor current ripples. On the other hand, common carrier-based multilevel modulations have been modified in terms of both reference and carrier signals to control the inverter under symmetric and asymmetric conditions. With... 

Cascaded split-source inverter (CSSI) is a new single-stage modular multilevel topology. Each cell of this converter converts dc to ac power in the buck or boost operation mode without any additional power switch. This article develops a design method based on a detailed model for CSSI. This model shows that energy storage elements experience double-fundamental frequency ripples besides high-frequency ones. It accurately calculates voltage gains and capacitor voltage and inductor current ripples. On the other hand, common carrier-based multilevel modulations have been modified in terms of both reference and carrier signals to control the inverter under symmetric and asymmetric conditions.... 

The leakage current and process variation are drastically increased with technology scaling. In Conventional SRAM cell due to process variations, stored data can be destroyed during read operation. Therefore, leakage current of SRAM cell and stability during read operation are two important parameters in nano-scaled CMOS technology. To overcome these limitations and to increase the speed of conventional SRAMs, we have developed a read-static-noise-margin-free SRAM cell. The developed cell has six-transistors and uses two read/write-lines and two read/write-bit-lines during read/write operation. This cell retains its data with leakage current and positive feedback without refresh cycle. The... 

In this paper, a two-dimensional, two-phase, non-isothermal model is presented to predict the electrochemical, mass transfer and heat transfer behaviors in a direct methanol fuel cell (DMFC). Governing equations including the momentum, continuity, heat transfer, proton and electron transport, species transport for water, methanol, and all the gas species (carbon dioxide, methanol vapor, water vapor, oxygen, and nitrogen) and the auxiliary equations are coupled to studying the various phenomena in DMFC. The modeling results agree well with the four different experimental data in an extensive range of operation conditions. A parametric study is also performed to examine the effects of the cell... 

The morphology of endothelial cells (ECs) may be an indication for determining atheroprone sites. Until now, there has been no clinical imaging technique to visualize the morphology of ECs in the arteries. The present study introduces a computational technique for determining the morphology of ECs. This technique is a multiscale simulation consisting of the artery scale and the cell scale. The artery scale is a fluid-structure interaction simulation. The input for the artery scale is the geometry of the coronary artery, that is, the dynamic curvature of the artery due to the cardiac motion, blood flow, blood pressure, heart rate, and the mechanical properties of the blood and the arterial... 

Molecular imaging (MI) can provide not only structural images utilizing temporal imaging techniques, but also functional and molecular data using a variety of newly developed imaging techniques. Nanotechnology’s application in MI has commanded a lot of attention in recent decades, and it has provided tremendous potential for imaging living subjects. In this study, D-glucosamine conjugated functionalized magnetic iron oxide nanoparticles (Fe3O4-PEG-DG NPs) were prepared and studied as magnetic resonance imaging (MRI) contrast agents. To evaluate their distribution, single-photon emission computed tomography (SPECT) is performed. Fe3O4 NPs are made using a well-known co-precipitation process... 

Microfluidic devices have received wide attention and shown great potential in the field of tissue engineering and regenerative medicine. Investigating cell response to various stimulations is much more accurate and comprehensive with the aid of microfluidic devices. In this study, we introduced a microfluidic device by which the matrix density as a mechanical property and the concentration profile of a biochemical factor as a chemical property could be altered. Our microfluidic device has a cell tank and a cell culture chamber to mimic both 2D to 3D and 3D to 3D migration of three types of cells. Fluid shear stress is negligible on the cells and a stable concentration gradient can be... 

Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture. Numerical simulations were performed to evaluate and optimize the design. Results showed a... 

The shape and morphology of endothelial cells (ECs) lining the blood vessels are a good indicator for atheroprone and atheroprotected sites. ECs of blood vessels experience both wall shear stress (WSS) and cyclic stretch (CS). These mechanical stimuli influence the shape and morphology of ECs. A few models have been proposed for predicting the morphology of ECs under WSS or CS. In the present study, a mathematical cell population model is developed to simulate the morphology of ECs under combined WSS and CS conditions. The model considers the cytoskeletal filaments, cell–cell interactions, and cell–extracellular matrix interactions. In addition, the reorientation and polymerization of... 

Aluminum reduction cells have benefited from point feeding technology for a long time, but there are still smelters which are using the old technology of center break and center feed system. Due to several factors this system is no longer approved and there have been a few attempts worldwide to upgrade these cells so as to implement the newer technology by applying mechanical and automation changes. In this paper we will present an attempt which was made in order to retrofit a so-called center break cell to point feeder cell. The results show that this project has decreased the energy consumption and anode effect frequency. Furthermore, there has been a significant increase in current... 

This paper presents a single-ended low-power 7T SRAM cell in FinFET technology. This cell enhances read performance by isolating the storage node from the read path. Moreover, disconnecting the feedback path of the cross-coupled inverters during the write operation enhances WSNM by nearly 7.7X in comparison with the conventional 8T SRAM cell. By using only one bit-line, this cell reduces power consumption and PDP compared to the conventional 8T SRAM cell by 82% and 35%, respectively. © 2018 Elsevier GmbH  

Based on the observation that dynamic occurrence of zeros in the cache access stream and cache-resident memory values of ordinary programs exhibit a strong bias towards zero, this paper presents a novel CMOS four-transistor (4T) SRAM cell for very high density and low power cache applications. This cell retains its data with leakage current and positive feedback without refresh cycle. The new cell size is 20% smaller than a conventional six-transistor cell using same design rules and delay access of a cache based on new 4T SRAM cell is 32% smaller than a cache based on 6T SRAM cell. Also the dynamic and static power consumption of new cell is 40% and 20% smaller than 6T SRAM cell,... 

Bias temperature instability (BTI) is known as one serious reliability concern in nanoscale technologies. BTI gradually increases the absolute value of threshold voltage (Vth) of MOS transistors. The main consequence of Vth shift of the SRAM cell transistors is the static noise margin (SNM) degradation. The SNM degradation of SRAM cells results in bit-flip occurrences due to transient faults and should be monitored accurately. This paper proposes a sensor called write current-based BTI sensor (WCBS) to assess the BTI-aging state of SRAM cells. The WCBS measures BTI-induced SNM degradation of SRAM cells by monitoring the maximum write current shifts due to BTI. The observations show that the...