Sharif Digital Repository

Recent advances in medical imaging techniques have allowed pure displacement-control trunk models to estimate spinal loads with no need to calculate muscle forces. Sensitivity of these models to the errors in post-imaging evaluation of displacements (reported to be ∼0.4–0.9° and 0.2–0.3 mm in vertebral displacements) has not yet been investigated. A Monte Carlo analysis was therefore used to assess the sensitivity of results in both musculoskeletal (MS) and passive finite element (FE) spine models to errors in measured displacements. Six static activities in upright standing, flexed, and extended postures were initially simulated using a force-control hybrid MS-FE model. Computed vertebral... 

This study presents a novel statistical volume element (SVE) for micromechanical modeling of the white matter structures, with histology-informed randomized distribution of axonal tracts within the extracellular matrix. The model was constructed based on the probability distribution functions obtained from the results of diffusion tensor imaging as well as the histological observations of scanning electron micrograph, at two structures of white matter susceptible to traumatic brain injury, i.e. corpus callosum and corona radiata. A simplistic representative volume element (RVE) with symmetrical arrangement of fully alligned axonal fibers was also created as a reference for comparison. A... 

In the present paper, a fully coupled numerical model is developed for the hydromechanical analysis of deforming, progressively fracturing porous media interacting with the flow of two immiscible, compressible wetting and non-wetting pore fluids. The governing equations involving the coupled two-phase fluid flow and deformation processes in partially saturated porous media containing cohesive cracks are derived within the framework of the generalized Biot theory. The displacement of the solid phase, the pressure of the wetting phase and the capillary pressure are taken as the primary unknowns of the three-phase formulation. A softening cohesive law is employed to describe the nonlinear...