Sharif Digital Repository

This study presents a novel statistical volume element (SVE) for micromechanical modeling of the white matter structures, with histology-informed randomized distribution of axonal tracts within the extracellular matrix. The model was constructed based on the probability distribution functions obtained from the results of diffusion tensor imaging as well as the histological observations of scanning electron micrograph, at two structures of white matter susceptible to traumatic brain injury, i.e. corpus callosum and corona radiata. A simplistic representative volume element (RVE) with symmetrical arrangement of fully alligned axonal fibers was also created as a reference for comparison. A... 

Biocompatible and biodegradable three-dimensional scaffolds are commonly porous which serve to provide suitable microenvironments for mechanical supporting and optimal cell growth. Silk fibroin (SF) is a natural and biomedical polymer with appropriate and improvable mechanical properties. Making a composite with a bioceramicas reinforcement is a general strategy to prepare a scaffold for hard tissue engineering applications. In the present study, SF was separately combined with titanium dioxide (TiO2) and fluoridated titanium dioxide nanoparticles (TiO2-F) as bioceramic reinforcements for bone tissue engineering purposes. At the first step, SF was extracted from Bombyx mori cocoons. Then,... 

This paper presents a bi-directional closed-form analytical solution, in the framework of nonlinear soft composites mechanics, for top-down hyperelastic characterization of brain white matter tissue components, based on the directional homogenized responses of the tissue in the axial and transverse directions. The white matter is considered as a transversely isotropic neo-Hookean composite made of unidirectional distribution of axonal fibers within the extracellular matrix. First, two homogenization formulations are derived for the homogenized axial and transverse shear moduli of the tissue, based on definition of the strain energy density function. Next, the rule of mixtures and... 

Effective prevention and treatment management of spinal disorders can only be based on accurate estimation of muscle forces and spinal loads during various activities such as lifting. The infeasibility of experimental methods to measure muscle and spinal loads has prompted the use of biomechanical modeling techniques. A major shortcoming in many previous and current models is the consideration of equilibrium conditions only at a single cross section, rather than along the entire length of the spine, when attempting to compute muscle forces and spinal loads. The assumption of extensor global muscles with straight rather than curved paths and of the spinal segments as joints with no... 

The use of micromechanical models to study composite material's behavior leads to save time and cost. In this paper, bridging micromechanical models have been used in order to observe the behavior of unidirectional laminate composite under fatigue loading. In order to study the fatigue behavior, stiffness degradation has been studied as well as the strength degradation and a driftnet model has been proposed for each of them. The strength degradation has only been studied for the unidirectional fiber, while the stiffness degradation has been studied for the fibers with different fiber angle. The results are compared with macro-mechanical models and other methods in literature  

An integrated model based on finite-element method has been proposed to examine the mechanical and thermal responses of strips and work-rolls in tandem and reverse cold rolling operations. The model has been developed such that the influence of various process parameters, such as lubrication, rolling speed, frictional state and back-up rolls, can be examined. Thermal behaviors of the rolled material and the work-rolls have been analyzed using stream-line upwind Petrov-Galerkin approach, in order to make the model applicable to high-speed rolling processes, as well. The results have been compared to the actual on-line measurements and shown to be of acceptable accuracy. Such modeling approach... 

It has been hypothesized that the muscular efforts exerted during standing may be altered by changes in personal factors, such as the body stature and muscular strength. The goal of this work was to assess the contribution of leg muscles using a biomechanical model in different physical conditions and various initial postures. An optimized inverse dynamics model was employed to find the maximum muscular effort in 23,040 postures. The simulation results showed that mid-range knee flexion could help the healthy and strong individuals maintain balance, but those with weaker muscle strength required more knee flexion. Individuals of weak muscular constitution as well as those with tall stature... 

Objective: To assess adequacy of the National Institute for Occupational Safety and Health (NIOSH) Lifting Equation (NLE) in controlling lumbar spine loads below their recommended action limits during asymmetric load-handling activities using a detailed musculoskeletal model, that is, the AnyBody Modeling System. Background: The NIOSH committee employed simplistic biomechanical models for the calculation of the spine compressive loads with no estimates of the shear loads. It is therefore unknown whether the NLE would adequately control lumbar compression and shear loads below their recommended action limits during asymmetric load-handling activities. Method: Twenty-four static stoop lifting... 

Objective: Spine kinematics, kinetics, and trunk muscle activities were evaluated during different stages of a fatigue-induced symmetric lifting task over time. Background: Due to neuromuscular adaptations, postural behaviors of workers during lifting tasks are affected by fatigue. Comprehensive aspects of these adaptations remain to be investigated. Method: Eighteen volunteers repeatedly lifted a box until perceived exhaustion. Body center of mass (CoM), trunk and box kinematics, and feet center of pressure (CoP) were estimated by a motion capture system and force-plate. Electromyographic (EMG) signals of trunk/abdominal muscles were assessed using linear and nonlinear approaches. The L5-S1... 

Several mathematical modeling approaches are used to model water resources systems such as deterministic and non-deterministic, lumped and distributed, steady and dynamic, simulation and optimization approaches. All these modeling paradigms - categorized as open systems - assume that the input conditions to the system will not change during their operation. What is happening in the real world is somewhat different. Due to their dynamic behaviors, real world events exert feedbacks from their outputs to their inputs which may cause the input conditions vary with time. This is the main focus of the system dynamics theory which has been introduced in this paper to be applied in water resources... 

Spinal posture including thorax/pelvis orientations as well as loads on the intervertebral discs are crucial parameters in biomechanical models and ergonomics to evaluate the risk of low back injury. In vivo measurement of spinal posture toward estimation of spine loads requires the common motion capture techniques and laboratory instruments that are costly and time-consuming. Hence, a closed loop algorithm including an artificial neural network (ANN) and fuzzy logic is proposed here to predict the L5–S1 segment loads and thorax/pelvis orientations in various 3D reaching activities. Two parts namely a fuzzy logic strategy and an ANN from this algorithm; the former, developed based on the... 

In this paper, a fully coupled thermo-hydro-mechanical model is presented for two-phase fluid flow and heat transfer in fractured/fracturing porous media using the extended finite element method. In the fractured porous medium, the traction, heat, and mass transfer between the fracture space and the surrounding media are coupled. The wetting and nonwetting fluid phases are water and gas, which are assumed to be immiscible, and no phase-change is considered. The system of coupled equations consists of the linear momentum balance of solid phase, wetting and nonwetting fluid continuities, and thermal energy conservation. The main variables used to solve the system of equations are solid phase... 

The lasing mechanism and temporal output profile of distributed feedback dye lasers is investigated, using a model based on induced polarization in the dye solution, where a more accurate behavior of the laser output is predicted. It is found that the temporal output profile of the laser is mostly determined by the concentration of dye solution and the lifetime of the upper laser level of dye molecules. To a large extent, the results of this work agree with experimental studies, even at high-level pump intensities where the self Q-switched model fails to be applied. Especially, the experimentally observed irregular intensity profile of laser output is explained. It is also shown that, when... 

Effects of molecular weight and structure of polyamide 6 (PA6) on morphology and properties of PA6/MWCNT prepared by melt mixing were investigated. Microscopic analysis showed fine dispersion of MWCNT within low viscosity PA6s due to domination of melt infiltration into MWCNT agglomerate at low viscosity matrices with linear structure. Rheological data indicated good interfacial interaction with no percolation of MWCNT up to 2 wt% loading. DSC thermograms showed nucleating role of MWCNT on crystallization of PA6s with marginal effect on crystallinity. Experimental data supported with micromechanical model showed limited improvement on mechanical properties, but it was closely consistent with... 

Epidemiological studies are divided over the causative role of body weight (BW) in low back pain. Biomechanical modeling is a valuable approach to examine the effect of changes in BW on spinal loads and risk of back pain. Changes in BW have not been properly simulated by previous models as associated alterations in model inputs on the musculature and moment arm of gravity loads have been neglected. A detailed, multi-joint, scalable model of the thoracolumbar spine is used to study the effect of BW (varying at five levels, i.e., 51, 68, 85, 102, and 119kg) on the L5-S1 spinal loads during various static symmetric activities while scaling moment arms and physiological cross-sectional areas of... 

Different lifting analysis tools are commonly used to assess spinal loads and risk of injury. Distinct musculoskeletal models with various degrees of accuracy are employed in these tools affecting thus their relative accuracy in practical applications. The present study aims to compare predictions of six tools (HCBCF, LSBM, 3DSSPP, AnyBody, simple polynomial, and regression models) for the L4-L5 and L5-S1 compression and shear loads in twenty-six static activities with and without hand load. Significantly different spinal loads but relatively similar patterns for the compression (R2>0.87) were computed. Regression models and AnyBody predicted intradiscal pressures in closer agreement with... 

This paper presents a three-dimensional micromechanical model of brain white matter tissue as a transversely isotropic soft composite described by the generalized Ogden hyperelastic model. The embedded element technique, with corrected stiffness redundancy in large deformations, was used for the embedment of a histology-informed probabilistic distribution of the axonal fibers in the extracellular matrix. The model was linked to a multi-objective, multi-parametric optimization algorithm, using the response surface methodology, for characterization of material properties of the axonal fibers and extracellular matrix in an inverse finite element analysis. The optimum hyperelastic... 

Traditional electromyography-assisted optimization (TEMG) models are commonly employed to compute trunk muscle forces and spinal loads for the design of clinical/treatment and ergonomics/prevention programs. These models calculate muscle forces solely based on moment equilibrium requirements at spinal joints. Due to simplifications/assumptions in the measurement/processing of surface EMG activities and in the presumed muscle EMG-force relationship, these models fail to satisfy stability requirements. Hence, the present study aimed to develop a novel stability-based EMG-assisted optimization (SEMG) method applied to a musculoskeletal spine model in which trunk muscle forces were estimated by... 

Ligaments assist trunk muscles in balancing external moments and providing spinal stability. In absence of the personalized material properties for ligaments, finite element (FE) models use dispersed data from the literature. This study aims to investigate the relative effects of eight different ligament property datasets on FE model responses. Eight L4-L5 models distinct only in ligament properties were constructed and loaded under moment (15 N m) alone or combined with a compressive follower load (FL). Range of motions (RoM) of the disc-alone model matched well in vitro data. Ligament properties significantly affected only sagittal RoMs (∼3.0–7.1° in flexion and ∼3.8–5.8° in extension at... 

The kinematics information from imaging, if combined with optimization-based biomechanical models, may provide a unique platform for personalized assessment of trunk muscle forces (TMFs). Such a method, however, is feasible only if differences in lumbar spine kinematics due to differences in TMFs can be captured by the current imaging techniques. A finite element model of the spine within an optimization procedure was used to estimate segmental kinematics of lumbar spine associated with five different sets of TMFs. Each set of TMFs was associated with a hypothetical trunk neuromuscular strategy that optimized one aspect of lower back biomechanics. For each set of TMFs, the segmental...