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Electrochemical Sensors Based on Electrodes Modified with Composites of Carbon Nanostructures and Polypyrrole; Application to Electrochemical Investigations and Determination of Nifedipine and Tizanidine

Shamloofard, Maryam | 2017

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 50074 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. In the first part, the electropolymerization of pyrrole was performed in the presence of Titan Yellow (TY) as a dopant anion on the surface of the electrode precoated with CNTs. The modified electrode was used to study the voltammetric response of tizanidine (TIZ). A remarkable increase was observed in the anodic peak current of TIZ on the surface of the modified electrode relative to the bare GCE. The surface morphology PPY/CNT/GCE was thoroughly characterized by scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques. Under the optimized analysis conditions, the modified electrode showed two linear dynamic ranges of 0.01 - 1 μM and 1-10 μM with a detection limit of 3 nM for the voltammetric determination of TIZ. The modified electrode was successfully applied for the accurate determination of trace amounts of TIZ in pharmaceutical and clinical preparations
    In the second part, the electrochemical behavior of Nifedipine (NIF) was investigated on the surface of the modified electrode with different carbon nanomaterials, including carbon nanotubes (CNTs), carbon nanoparticles (CNPs), nanodiamond-graphite (NDG) and reduced graphene oxide (rGO) using cyclic voltammetry (CV). The results of voltammetric studies exhibited a considerable increase in the chatodic peak current of NIF on the surface of the modified electrode with CNPs compared to the other modified electrodes and also bare GCE. The CNPs modified electrode was employed for the voltammetric determination of NIF. The surface morphology and nature of the CNPs film was thoroughly characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Under the optimized analysis conditions, the modified electrode showed linear dynamic ranges of 0.01 - 1.5 μM with a detection limit of 3 nM for the voltammetric determination of NIF. The modified electrode was successfully applied for the accurate determination of trace amounts of NIF in pharmaceutical and clinical preparations
  9. Keywords:
  10. Carbon Nanomaterials ; Carbon Nanotubes ; Carbon Nanoparticles ; Modified Electrodes ; Tizanidine ; Polypyrrole ; Nifedipine

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