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Development of Extended Release System for Aspirin

Poursadeghian, Arezou | 2018

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 50945 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abdekhodaie, Mohammad Jafar; Hemmati, Ali Asghar
  7. Abstract:
  8. Today, in order to increase the effectiveness of the drug and reduce its side effects, modern drug delivery systems replace the traditional methods of drug production. Some of these systems are designed to allow their drug release to proceed gradually and prolonged, so that its concentration in the blood remains at a relatively constant level and preserves the therapeutic effect of the drug. Aspirin or acetylsalicylic acid is a non-steroidal anti-inflammatory drug (NSAIDs). Aspirin is widely used to prevent secondary heart attacks and stroke and reduce the risk of death in patients with chronic coronary artery disease and stroke. Aspirin is used as an anticoagulant agent for patients with cardiovascular disease. Aspirin extended- release system can be improved release system performance and reduce side effects, that the aim of this research is to develop an extended-release system for aspirin. Due to the existence of a foreign sample of aspirin (DURLAZA), as well as the expensive price and new technology of this brand of medicine and its widespread market, the aim of this research is to achieve the technology of making this drug in Iran. Consequently, microcapsules containing aspirin particles coated with ethylcellulose polymer and excipients present in Durlaza were made by air suspension method and dissolution test was performed according to FDA approved tests. The dissolution tests results were compared with the original sample release chart and were interpreted based on zero order, first order, and Higuchi kinetic models. Since the Durleza release profile is more accordance with the first order and Higuchi models, Therefore, the conformance of the release profiles of the samples obtained with Durlaza was investigated by these models. Among these samples, the product obtained from the third experiment (R3) was closer to the original product than the rest
  9. Keywords:
  10. Extended Release System ; Encapsulation ; Microencapsulation ; Aspirin

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