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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 51509 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Frounchi, Masoud; Dadbin, Sousan
- Abstract:
- In recent years along with time and cost intensive process of developing new and better drugs for diseases like cancer, scientists and researchers are attempting to develop novel drug delivery systems for already existing drugs.The purpose of these novel drug delivery systems such as nanogels is controlling drug release rate as well as delivery to a specific target tissue in order to reduce side effects. One of the most commonly used drugs for cancer treatment is Doxorubicin HCl, commercially known as Adricin. In this project biodegradable and biocompatible polymers PLA and PEG were used to synthesize nanocarriers for Adricin. These nanocarriers were then dispersed in an agar hydrogel. The required analyses were performed to characterize the drug delivery system. Incorporation of drug into polymer matrix was confirmed using FTIR analysis. SEM imaging showed that nanocarriers were spherical in shape and DLS analysis conformed nanospheres of mean diameter of nm. Using DSC analysis, effects of drug loading and PEG presence on crystallization percentage as well as glass transition temperature and melting temperature of PLA was investigated. Encapsulation efficiency was also determined. In vitro drug release examinations were conducted that indicated improved encapsulation efficiency and drug release in PEG presence
- Keywords:
- Doxorubicin ; Agar ; Polylactic Acid ; Polyethylen Glycol (PEG) ; Drug Delivery ; Nanogel ; Novel Drug Delivery ; Adricin
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