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Super-porous semi-interpenetrating polymeric composite prepared in straw for micro solid phase extraction of antibiotics from honey, urine and wastewater

Asgari, S ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.chroma.2020.461576
  3. Publisher: Elsevier B.V , 2020
  4. Abstract:
  5. A cryogel–based semi–interpenetrating polymer network (Cryo–SIPN) was prepared in which conductive polymers such as polyaniline (PANI) and polypyrrole (PPy) were formed within the super porous network of acrylic acid cryogel. For completion of cryo-polymerization, all the constituent solutions were severely mixed and placed into the plastic straws and kept at -20°C and then the synthesized cyrogels were cut into the 1-cm length and freeze dried after washing with water. The Cryo–SIPN polymeric composite was applied in micro solid phase extraction (µSPE) of some selected antibiotic residues from various samples. The µSPE method combined with a high performance liquid chromatography–ultraviolet (HPLC–UV) system allowed trace quantification of antibiotic residues in the honey and water samples while the significant variables were optimized using a central composite design (CCD) to find optimum conditions. The method performance was satisfactory with recovery ranges from 70.0 to 109%. The limits of detection (S/N = 3) and quantification (S/N = 10) for all samples were within the 17–50 μg kg−1 and 47–140 μg kg−1 range, respectively. The relative standard deviation was less than 10 % for antibiotics in the foodstuff and water samples. The validated Cryo–SIPN–µSPE in conjunction with HPLC–UV, proved to be versatile, efficient and robust while its capability toward the trace determination of drugs residues in real-life samples is demonstrated in this work. © 2020 Elsevier B.V
  6. Keywords:
  7. Antibiotic residues ; Cryogel ; Honey ; Semi–interpenetrating polymer network ; µ–Solid phase extraction ; Antibiotics ; Food products ; High performance liquid chromatography ; Phase separation ; Polyaniline ; Polypyrroles ; Reinforced plastics ; Central composite designs ; Limits of detection ; Micro-solid-phase extractions ; Polymeric composites ; Relative standard deviations ; Significant variables ; Trace determination ; Extraction ; Acrylic acid ; Antibiotic agent ; Cefalexin ; Cefixime ; Ciprofloxacin ; Cloxacillin ; Drug residue ; Penicillin derivative ; Polymer ; Polypyrrole ; Adsorption ; Article ; Central composite design ; Desorption ; Experimental design ; Factorial design ; Food safety ; Freeze drying ; Limit of detection ; Limit of quantitation ; Plastic straaw ; Polymerization ; Priority journal ; Solid phase microextraction ; Urine ; Waste water
  8. Source: Journal of Chromatography A ; Volume 1631 , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0021967320308505