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Targeted Theranostic Delivery System Based on Liposomes Containing Graphene Quantum Dots and Drug Nanoparticles For Monitoring and Treatment of Breast Cancer

Ramedani, Arash | 2022

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 55894 (48)
  4. University: Sharif University of Technology
  5. Department: Institute for Nanoscience and Nanotechnology
  6. Advisor(s): Simchi, Abdolreza; Sabzevari, Omid
  7. Abstract:
  8. Theranostic liposomes have recently found a broad range of applications in nanomedicine due to stability, the high solubility of biomacromolecules, bioavailability, efficacy, and low adverse effects. However, the limitations of liposomes concerning the short systemic circulation in the body, limited controllability of the release rate, and the inability of in vivo imaging remain challenging. Herein, the development of novel hybrid ultrasound-activated piezoelectric nanoparticles based on a hybrid liposome nanocarrier composed of poly(vinylidene fluoride‐trifluoroethylene), graphene quantum dots (GQDs), and Silibinin (a hydrophobic drug) is presented. The hybrid nanoparticles are an acoustically sensitive drug delivery platform that releases the biomacromolecules in a specific tissue area (through surface labeling with PD-1 antibody) in a non-invasive and controlled manner. We show that the developed hybrid nanoparticles (with an average outer diameter of ~200 nm) enable piezoelectric-stimulated drug delivery combined with simultaneous fluorescent imaging of cancer cells in vivo. Significant enhancement (>80% up to 240 h) and tunable release of the drug from the nanocarrier through enhanced diffusion from the liposome membrane are demonstrated. Cytotoxicity assays using MCF-7, 4T1, and NIH3T3 cell lines exhibit no confrontational influence of nanoparticles on cell viability up to 125 µg/ml. Because of the presence of PD-1 antibody on the surface of hybrid nanocarrier, a high uptake into breast cancer tumors and low biodistribution in other organs are attained. Our results affirm that the developed ultrasound-activated piezoelectric nanoparticles have great potential as multifunctional platforms with sustainable release profiles for the delivery of hydrophobic drugs to breast cancer, especially when the ability for adequate labeling and cell monitoring is valued
  9. Keywords:
  10. Surface Chemisty ; Carbon Nanostructures ; Drug Delivery ; Breast Cancer ; Cancer Treatment ; Theranostic Systems ; Stimuli-Responsive ; Stimuli-Sensitive ; Liposoms ; Graphene Quantum Dots (GQDs) ; Piezoelectric

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