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Design and Fabrication Nanocomposite Modified Electrode Materials Based on Transition Metal Phosphide Using Copper Hydroxide Nanotubes as a Catalytic Substrate for Glucose Sensing in Non-Enzymatic Sensors

Kazemi Abatari, Zeynab | 2023

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 56011 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. In this study, transition metal phosphide, with a high accessible surface and abundant electroactive centers, was used as an electrocatalyst to fabrication an electrochemical sensor of Gloucose. The direct growth of thin film of nanocomposite can be considered as an efficient method to modify the electrode surface, and the application of these modified electrodes as electrochemical sensors. nanocomposite of transition metal phosphide (CuCoP) were directly grown on Cu(OH)2 nanotubes (as-prepared on GCE) in order to design hierarchical core-shell nanostructure with using efficient, inexpensive and fast method. Here, Cu(OH)2 nanotubes not only served as substrate, but also steer the CuCoP to attach on nanotubes surface preferentially. growth of Bimetallic phosphideson the naturally porous and conductive Cu(OH)2 nanotubes make the efficient use of electroactive materials possible due to not only, highly porous 3D configuration, but also, the synergistic effect between the core and the shell structurers. This direct growth of hierarchical core-shell CuCoP@Cu(OH)2 nanostructures on the GCE surface without requirement of any binder or additive layer make efficient use of electrocatalyst materials. Due to the unique properties of the prepared CuCoP@Cu(OH)2 thin film electrode such as uniform and vertically aligned structure, excellent stability, high electroactive surface area, and good availability to analyte and electrolyte diffusion, it was directly used as the electrode material for non-enzymatic electrocatalytic oxidation of glucose. Moreover, the potential utility of this sensing platform for the analytical determination of glucose concentration was evaluated by the amperometry technique. The designed electrode demonstrated two wide linear dynamic range of 0.001 mM – 0.105 mM and 0.105 mM–2.530 mM with high sensitivity of 8351 μAmM-1cm-2 and 3932 μAmM-1cm-2, respectively, good repeatability and reproducibility, high selectivity against interference species and good poisoning resistance against chloride ions and a low detection limit of 2.3 μM (S/N = 3). In addition, the electrode showed a very fast response time of 2 seconds. The obtained results promise the applicability of the sensor designed based on CuCoP @Cu(OH)2 as a reliable and efficient sensor for detecting and measuring glucose. Finally, in order to examine the ability of the modified electrode in practical applications, the human blood serum samples were analyzed and results show that the fabricated electrode can be used as a reliable and applicable sensing platform for the determination of glucose in physiological samples
  9. Keywords:
  10. Glassy Carbon Electrode ; Modified Electrodes ; Electrocatalysts ; Nano Catalyst ; Nonenzymatic Sensor ; Glucose ; Transition Metal Phosphide ; Copper Hydroxide Nanotubes

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