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Intra-Articular Drug Delivery System for the Treatment of Inflammatory Arthritis

Shiri Varnamkhasti, Atefeh | 2024

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57133 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Abdekhodaie, Mohammad Jafar
  7. Abstract:
  8. The objective of this research is to design a drug delivery system that allows anti-inflammatory drugs to be injected directly into the joint (intra-articular injection) for the treatment of arthritis so that reduce the side effects associated with oral consumption of these drugs, increase the duration of drug retention in the joint environment, and reduce the side effects caused by repeated injections while improving effectiveness. To achieve this, first, desirable features were determined by considering the anatomy of the joint environment, the biological changes caused by the disease, and reviewing published articles and commercial products in the field; appropriate drug and raw materials were then selected to design and optimize the desired system. Ascorbyl palmitate was chosen as the carrier for the anti-inflammatory drug, triamcinolone acetonide, to provide controlled and long-term release of the drug, and Hyaluronic acid was added to the system in order to provide protection of the cartilage and joint against friction, in this regard, two systems were proposed, both using the self-assembled structure of ascorbyl-palmitate as a drug carrier; in the first system, cross-linked hyaluronic acid microparticles were added to improve the system's performance in preventing joint wear and In the second system, the self-assembly process of ascorbyl palmitate occurred in the presence of hyaluronic acid solution. The drug release profile and rheological properties of the proposed systems were evaluated and compared with each other and to commercial products too. The study found that the second proposed system performed well in terms of the drug release profile and reducing friction between the joint heads. So it is expected that this system would improve the efficiency of arthritis treatment
  9. Keywords:
  10. Arthritis ; Inflammation ; Drug Delivery ; Hyaluronic Acid Gel ; Ascorbyl Palmitate ; Rheological Properties

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