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Evaluation of ascorbic acid-loaded calcium phosphate bone cements: Physical properties and in vitro release behavior

Hemmati, K ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.ceramint.2013.08.042
  3. Abstract:
  4. In this study, different concentrations of ascorbic acid (50, 100 and 200 μg/mL) were added to the liquid phase of a calcium phosphate cement (CPC). The cements were immersed in simulated body fluid (SBF) for different intervals and physical, physicochemical and mechanical properties of them were evaluated. The release of added ascorbic acid from CPCs into the SBF solution was also studied. From the results, both setting time and injectability of CPC decreased by adding ascorbic acid, however the compressive strength was sharply increased before soaking in SBF solution. But, the compressive strength values of all cements (with or without ascorbic acid) soaked in SBF solution for more than 7 d duration were comparable. The X-ray diffractometry results showed that in vitro apatite formation ability of cement reactants did not change by adding ascorbic acid. The scanning electron microscopy images indicated that morphology of the formed apatite crystals was nano-needlelike and needle diameter was less than 100 nm. The loaded ascorbic acid was slowly released from CPC into the SBF solution so that about 10% and 20% of the loaded drug was released after 504 h for the cements containing 100 and 200 μg/mL ascorbic acid, respectively. The release rate was increased when the amount of added ascorbic acid decreased by 50 μg/mL
  5. Keywords:
  6. Apatite formation ; Bone substitutes ; Calcium phosphate bone cement ; Calcium phosphate cement ; Nano apatite ; Physico-chemical and mechanical properties ; Scanning electron microscopy image ; Simulated body fluids ; Apatite ; Bioactivity ; Bone cement ; Calcium phosphate ; Cements ; Compressive strength ; Drug delivery ; Mechanical properties ; Scanning electron microscopy ; X ray diffraction analysis ; Ascorbic acid
  7. Source: Ceramics International ; Vol. 40, issue. 3 , April , 2014 , pp. 3961-3968 ; ISSN: 02728842
  8. URL: http://www.sciencedirect.com/science/article/pii/S0272884213009899