Loading...

Synthesis of novel pentacyclic thiopyrano indole-annulated benzo-δ-sultone derivatives via a domino Knoevenagel-hetero-Diels-Alder reaction in water

Moghaddam, F. M ; Sharif University of Technology | 2013

1532 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.tetlet.2013.03.070
  3. Publisher: 2013
  4. Abstract:
  5. An efficient synthesis of novel pentacyclic thiopyrano indole-annulated benzo-δ-sultone derivatives is achieved via intramolecular domino Knoevenagel-hetero-Diels-Alder reaction of 2-formylphenyl (E)-2-phenylethenyl sulfonates and indoline-2-thiones in aqueous medium. The products are formed in good yields with high regio- and stereoselectivity
  6. Keywords:
  7. Aqueous medium ; Benzo-δ-sultones ; Domino reaction ; Indoline-2-thiones ; Knoevenagel-hetero-Diels-Alder ; Thiopyrano indole ; 2 Formylphenyl 2 phenylethenyl sulfonate ; Indole derivative ; Indoline 2 thione ; Pentacyclic thiopyrano indole annulated benzo delta sultone derivative ; Solvent ; Sultone ; Unclassified drug ; Water ; Annulation reaction ; Aqueous solution ; Catalyst ; Controlled study ; Cross linking ; Diels Alder reaction ; Knoevenagel condensation ; Stereochemistry ; Alnus
  8. Source: Tetrahedron Letters ; Volume 54, Issue 21 , 2013 , Pages 2685-2689 ; 00404039 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0040403913004723