Loading...

Iodine-131 radiolabeling of poly ethylene glycol-coated gold nanorods for in vivo imaging

Eskandari, N ; Sharif University of Technology | 2013

1257 Viewed
  1. Type of Document: Article
  2. DOI: 10.1002/jlcr.3006
  3. Publisher: 2013
  4. Abstract:
  5. Gold nanorods (GNRs) can be used in various biomedical applications; however, very little is known about their in vivo tissue distribution by radiolabeling. Here, we have developed a rapid and simple method with high yield and without disturbing their optical properties for radiolabeling of gold rods with iodine-131 in order to track in vivo tissue uptake of GNRs after systemic administration by biodistribution analysis and γ-imaging. Following intravenous injection into rat, PEGylated GNRs have much longer blood circulation times. We have developed a rapid and simple method for radiolabeling of gold rods with iodine-131 in order to track in vivo tissue uptake of gold nanorods after systemic administration by biodistribution analysis and γ-imaging. Copyright
  6. Keywords:
  7. V-imaging ; Radiolabeling ; Glycol ; Gold nanoparticle ; Gold nanorod ; Iodine 131 ; Nanocoating ; Polyethylene ; Unclassified drug ; Circulation time ; Gamma scintigraphy ; In vivo study ; Isotope labeling ; Isotope tracing ; Molecular imaging ; Nanochemistry ; Guantum yield ; Radiochemistry ; Surface property ; Animals ; Gold ; Iodine Radioisotopes ; Metal Nanoparticles ; Polyethylene Glycols ; Radiopharmaceuticals ; Rats ; Tissue distribution ; Biodistribution ; Gold nanorods ; Radiolabeling
  8. Source: Journal of Labelled Compounds and Radiopharmaceuticals ; Volume 56, Issue 1 , 2013 , Pages 12-16 ; 03624803 (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3006/abstract;jsessionid=053F9883E781791C9AB2970BF6AAD9A0.f04t03?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+5th+December+from+10%3A00-14%3A00+GMT+%2F+05%3A00-09%3A00+EST+%2F+18%3A00-22%3A00+SGT+for+essential+maintenance.+Apologies+for+the+inconvenience