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Simulation of red blood cell deformation in microvessels using a new rapid modified particle method

Firoozbakhsh, K ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1115/IMECE2011-63540
  3. Abstract:
  4. The deformation of human red blood cell has been a topic of considerable scientific interest and real-life significance. Several methods have been improved to simulate the behavior of red blood cells motion and deformation in micro-capillaries. Since in microscopic scales, using discrete models are more preferred than continuum methods, moving particle semiimplicit method (MPS) which is one of the recent innovative particle based methods, can simulate micro-fluidic flows based on Navier-Stocks equations. It has been shown that original MPS method has a lack of rapid calculation which leads to massive calculations and long time simulation. Quite a few studies have been done to improve MPS method. But the main problem, calculation of viscosity effect in conjunction with fluid pressure distribution, is still under discussion. In this paper a new algorithm is proposed that is to say by this method simulation duration decreases by the factor of 20 while the accuracy of the results remains constant. The results indicate that while the velocity precision is as well as original method, the duration of simulation is reduced more than 20 times. This significant novel MPS algorithm can be implemented in future studies for simulation of multi-fluid flows, complex geometry flows and micro-scale biomedical phenomena
  5. Keywords:
  6. Complex geometries ; Continuum method ; Discrete models ; Human red blood cell ; Micro-capillaries ; Micro-scales ; Microscopic scale ; Microvessels ; Moving particle semiimplicit method ; Multi-fluid flow ; Particle methods ; Particle-based methods ; Red blood cell ; Time simulations ; Viscosity effects ; Algorithms ; Blood ; Cells ; Exhibitions ; Mechanical engineering ; Deformation
  7. Source: ASME 2011 International Mechanical Engineering Congress and Exposition, IMECE 2011, 11 November 2011 through 17 November 2011 ; Volume 6, Issue PARTS A AND B , November , 2011 , Pages 1087-1090 ; 9780791854921 (ISBN)
  8. URL: http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=1644136