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Alginate-based biodegradable superabsorbents as candidates for diclofenac sodium delivery systems

Pourjavadi, A ; Sharif University of Technology | 2010

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  1. Type of Document: Article
  2. DOI: 10.1002/app.32205
  3. Publisher: 2010
  4. Abstract:
  5. Novel types of highly swelling hydrogels were prepared by grafting crosslinked polyacrylamide-co-poly-2-acrylamido-2-methylpropane sulfonic acid (PAAm-co-PAMPS) chains onto sodium alginate (Na-Alg) through a free radical polymerization method. The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FTIR). The controlled release behavior of diclofenac sodium (DS) from superabsorbent polymer was factinvestigated, and shown that the release profiles of DS from superabsorbent polymer were slow in simulated gastric fluid (SGF, pH 1.2) over 3 h, but nearly all of the initial drug content was released in simulated intestinal fluid (SIF, pH 7.4) within 21 h after changing media. Overall the results demonstrated that biodegradable superabsorbent could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be potential candidates as an orally administrated drug delivery system
  6. Keywords:
  7. Polysaccharide ; Control release ; Controlled release ; Crosslinked ; Delivery systems ; Diclofenac sodium ; Drug content ; Drug delivery system ; Fourier transform infrared ; FTIR ; Gastric fluids ; Intestinal fluid ; Polyacry lamide ; Radical polymerization ; Release profiles ; Sodium alginates ; Sulfonic acid ; Super absorbent ; Superabsorbent polymer ; Superabsorbents ; Butane ; Crosslinking ; Drug delivery ; Fourier transforms ; Free radicals ; Hydrogels ; Polymers ; Sodium ; Free radical polymerization
  8. Source: Journal of Applied Polymer Science ; Volume 118, Issue 4 , 2010 , Pages 2015-2023 ; 00218995 (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/app.32205/abstract;jsessionid=E299B9D779EAA5EE98D11CFFB1E035FB.f04t03