Loading...

PH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents

Karimi, M ; Sharif University of Technology | 2016

1921 Viewed
  1. Type of Document: Article
  2. DOI: 10.1002/wnan.1389
  3. Publisher: Wiley-Blackwell , 2016
  4. Abstract:
  5. In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual pH-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as Alzheimer's. In order to design an optimized system, it is necessary to understand the various pH-responsive micro/nanoparticles and the different mechanisms of pH-sensitive drug release. This should be accompanied by an assessment of the theoretical and practical challenges in the design and use of these carriers. WIREs Nanomed Nanobiotechnol 2016, 8:696–716. doi: 10.1002/wnan.1389. For further resources related to this article, please visit the WIREs website
  6. Keywords:
  7. Biomolecules ; Disease control ; Gene therapy ; Magnetic levitation vehicles ; Metal ions ; Metals ; PH sensors ; Proteins ; Redox reactions ; Anti-cancer agents ; Delivery vehicle ; Different mechanisms ; Mechanical force ; Physiological differences ; Stimuli-responsive ; Targeted delivery ; Therapeutic agents ; Nanosystems ; Drug ; Inorganic nanoparticle ; Liposome ; Nanocarrier ; Nanoparticle ; PH sensitive nanocarrier ; Polymeric micelle ; Polymeric nanoparticle ; Prodrug ; Pyridine derivative ; Unclassified drug ; Cancer cell ; Cell PH ; Drug conjugation ; Drug design ; Drug release ; Drug solubility ; Extracellular PH ; Human ; Malignant neoplastic disease ; Nonhuman ; PH ; Polymerization ; Priority journal ; Review
  8. Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology ; Volume 8, Issue 5 , 2016 , Pages 696-716 ; 19395116 (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/wnan.1389/abstract;jsessionid=F1EEC159B79A09B71E221168877BE5D1.f02t02?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+and+Sunday+i.e+16th+and+17th+September+at+3%3A00+EDT+%2F+8%3A00+BST+%2F+12%3A30+IST+%2F+15%3A00+SGT+for+5+hours+and+3hours+for+essential+maintenance.+Apologies+for+any+inconvenience+caused+