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NMR- and GC/MS-based metabolomics of sulfur mustard exposed individuals: a pilot study

Nobakht, B. F ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.3109/1354750X.2016.1153725
  3. Publisher: Taylor and Francis Ltd
  4. Abstract:
  5. Sulfur Mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and healthy controls are observed are related to lipid metabolism, ketogenesis, tricarboxylic acid (TCA) cycle and amino acid metabolism
  6. Keywords:
  7. Human serum ; Metabolomics ; Nuclear magnetic resonance ; Sulfur mustard ; Amino acid ; Biological marker ; Chemical warfare agent ; Lipid ; Mustard gas ; Blood ; Case control study ; Chemically induced ; Environmental exposure ; Human ; Lung Diseases ; Male ; Mass fragmentography ; Metabolomics ; Middle aged ; Nuclear magnetic resonance spectroscopy ; Pilot study ; Adult ; Biomarkers ; Gas Chromatography-Mass Spectrometry ; Magnetic Resonance Spectroscopy ; Pilot Projects
  8. Source: Biomarkers ; Volume 21, Issue 6 , 2016 , Pages 479-489 ; 1354750X (ISSN)
  9. URL: http://www.tandfonline.com/doi/abs/10.3109/1354750X.2016.1153725?journalCode=ibmk20