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Simultaneous evaluation of magnesia and silica contents’ effect on in-vitro bioactivity of novel bioglasses in the SiO2-CaO-MgO system

Eslami, M ; Sharif University of Technology | 2016

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  1. Type of Document: Article
  2. DOI: 10.1080/0371750X.2015.1131628
  3. Publisher: Taylor and Francis Ltd , 2016
  4. Abstract:
  5. In this study, bioglasses in SiO2-CaO-MgO system were synthesized through sol-gel method and the effect of silica and magnesia contents on in-vitro bioactivity of the bioglasses were investigated. XRD patterns showed an amorphous structure after heat treatment at 600°C for 2 h for all glasses and also indicated that after immersion in SBF, apatite particles precipitated on glass surfaces and the rate of apatite formation decreased with increasing Mg/Ca ratio. On the other hand, the apatite formation rate was enhanced with increasing the silica content. Furthermore, magnesia contents increased the compressive strength of the samples. According to SEM, higher Mg/Ca ratio led to increase in particle size of the precipitated apatite. MTT assay showed that cell proliferation was inhibited with increasing Mg/Ca ratio, however, silica contents stimulated the osteoblast proliferation. Â
  6. Keywords:
  7. Apatite ; Bioactive glass ; Bioactivity ; Cell proliferation ; Compressive strength ; Glass ; Particle size ; Phosphate minerals ; Silica ; Sol-gel process ; Sol-gels ; After-heat treatment ; Amorphous structures ; Apatite formation ; Glass surfaces ; In-vitro bioactivity ; Mg/ca ratios ; Osteoblast proliferation ; Silica content ; Magnesia
  8. Source: Transactions of the Indian Ceramic Society ; Volume 75, Issue 1 , 2016 , Pages 7-11 ; 0371750X (ISSN)
  9. URL: http://www.tandfonline.com/doi/abs/10.1080/0371750X.2015.1131628