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Injectable polyethylene glycol-laponite composite hydrogels as articular cartilage scaffolds with superior mechanical and rheological properties

Nojoomi, A ; Sharif University of Technology | 2017

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  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2016.1182914
  3. Publisher: Taylor and Francis Inc , 2017
  4. Abstract:
  5. In this study, injectable PEG-based hydrogels containing Laponite particles with mechanical and structural properties close to the natural articular cartilage are introduced. The nanocomposites are fabricated by imide ring opening reactions utilizing synthesized copolymers containing PEG blocks and nanoclay through a two-step thermal poly-(amic acid) process. Butane diamine is used as nucleophilic reagent and hydrogels with interconnected pores with sizes in the range of 100–250 µm are prepared. Improved viscoelastic properties compared with the conventional PEG hydrogels are shown. Evaluation of cell viability utilizing human mesenchymal stem cells determines cytocompatibility of the nanocomposite hydrogels. © 2017, Copyright © Taylor & Francis Group, LLC
  6. Keywords:
  7. Nanoclay ; Polyethylene glycol ; Cartilage ; Cell culture ; Nanocomposites ; Nanostructured materials ; Polyethylene glycols ; Polyethylene oxides ; Polyethylenes ; Rheology ; Stem cells ; Tissue engineering ; Viscoelasticity ; Cartilage tissue engineering ; Human mesenchymal stem cells ; Nano clays ; Nanocomposite hydrogels ; Nucleophilic reagent ; Rheological property ; Ring opening reaction ; Viscoelastic properties ; Hydrogels
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 66, Issue 3 , 2017 , Pages 105-114 ; 00914037 (ISSN)
  9. URL: https://www.tandfonline.com/doi/abs/10.1080/00914037.2016.1182914?journalCode=gpom20