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Metabolic profiling of seminal plasma from teratozoospermia patients

Mehrparvar, B ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jpba.2019.112903
  3. Publisher: Elsevier B. V , 2020
  4. Abstract:
  5. Teratozoospermia is one of conditions that can cause male infertility. The mechanism of teratozoospermia remains unclear. The knowledge of the metabolites in human seminal plasma (HSP) is meaningful for the pathological study of teratozoospermia. Analysis of changed metabolites in HSP can help understand the cellular mechanism, find the novel biomarkers and subsequently design a diagnosis test. In this study, the analysis of samples performed by proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) to identify the various metabolites, with the aim of finding metabolic profiles and biomarkers related to male infertility. Eighteen de-regulated metabolites were identified in fertile men compared to teratozoospermia patients. These changes illustrate the deficiencies in absorption or metabolism of these metabolites in teratozoospermia. Furthermore, metabolic profiling showed that it is not possible to classify teratozoospermia based on teratozoospermia index (TZI). To the best of our knowledge, this is the first metabolic profiling analysis of HSP described the metabolic features of teratozoospermia in a holistic view. © 2019 Elsevier B.V
  6. Keywords:
  7. Human seminal plasma ; Male infertility ; Metabolomics ; Teratozoospermia ; Biological marker ; Controlled study ; Human cell ; Metabolic fingerprinting ; Multivariate analysis ; Proton nuclear magnetic resonance ; Seminal plasma ; Nuclear magnetic resonance spectroscopy ; Sperm ; Spermatozoon abnormality ; Biomarkers ; Magnetic Resonance Spectroscopy ; Proton Magnetic Resonance Spectroscopy ; Semen
  8. Source: Journal of Pharmaceutical and Biomedical Analysis ; Volume 178 , January , 2020
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0731708519318692