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Point-of-use rapid detection of sars-cov-2: Nanotechnology-enabled solutions for the covid-19 pandemic

Rabiee, N ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.3390/ijms21145126
  3. Publisher: MDPI AG , 2020
  4. Abstract:
  5. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the global healthcare urgency, several techniques, including whole genome sequencing and computed tomography imaging have been employed for diagnosing infected people. Considerable efforts are also directed at detecting and preventing different modes of community transmission. Among them is the rapid detection of virus presence on different surfaces with which people may come in contact. Detection based on non-contact optical techniques is very helpful in managing the spread of the virus, and to aid in the disinfection of surfaces. Nanomaterial-based methods are proven suitable for rapid detection. Given the immense need for science led innovative solutions, this manuscript critically reviews recent literature to specifically illustrate nano-engineered effective and rapid solutions. In addition, all the different techniques are critically analyzed, compared, and contrasted to identify the most promising methods. Moreover, promising research ideas for high accuracy of detection in trace concentrations, via color change and light-sensitive nanostructures, to assist fingerprint techniques (to identify the virus at the contact surface of the gas and solid phase) are also presented. © 2020 by the authors. Licensee MDPI, Basel, Switzerland
  6. Keywords:
  7. COVID-19 ; Nanoparticles ; Nanotechnology ; Point-of-use ; Rapid detection of virus ; SARS-CoV-2 ; angiotensin converting enzyme 2 ; CRISPR associated protein ; Genomic RNA ; Graphene oxide ; Immunoglobulin G ; Immunoglobulin M ; Magnetic nanoparticle ; Metal organic framework ; Nucleocapsid protein ; Polyclonal antibody ; RNA directed RNA polymerase ; Silver nanoparticle ; Metal nanoparticle ; Virus RNA ; Chemical interaction ; Computer assisted tomography ; Coronavirus disease 2019 ; Cytotoxicity ; DNA microarray ; Enzyme linked immunosorbent assay ; Gene sequence ; Gene silencing ; Loop mediated isothermal amplification ; Microarray analysis ; Middle East respiratory syndrome ; nucleic acid amplification ; Pandemic ; Photon correlation spectroscopy ; Point of care testing ; Prevalence ; Raman spectrometry ; Real time polymerase chain reaction ; RNA extraction ; Rolling circle amplification ; Severe acute respiratory syndrome coronavirus 2 ; Single nucleotide polymorphism ; Three-dimensional imaging ; Transmission electron microscopy ; Turbidimetry ; Virus replication ; Whole genome sequencing ; Betacoronavirus ; Chemistry ; Coronavirus infection ; Genetics ; Point of care system ; Procedures ; Virus genome ; Virus pneumonia ; Coronavirus Infections ; Genome, Viral ; Metal Nanoparticles ; Metal-Organic Frameworks ; Nanotechnology ; Pandemics ; Pneumonia, Viral ; Point-of-Care Systems ; RNA, Viral ; Whole Genome Sequencing
  8. Source: International Journal of Molecular Sciences ; Volume 21, Issue 14 , 2020 , Pages 1-23
  9. URL: https://www.mdpi.com/1422-0067/21/14/5126