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Modeling the Parkinson's tremor and its treatments

Haeri, M ; Sharif University of Technology | 2005

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jtbi.2005.03.014
  3. Publisher: 2005
  4. Abstract:
  5. In this paper, we discuss modeling issues of the Parkinson's tremor. Through the work we have employed physiological structure as well as functioning of the parts in brain that are involved in the disease. To obtain more practical similarity, random behaviors of the connection paths are also considered. Medication or treatment of the disease both by drug prescription and electrical signal stimulation are modeled based on the same model introduced for the disease itself. Two new medication strategies are proposed based on the model to reduce the side effects caused by the present drug prescription. © 2005 Elsevier Ltd. All rights reserved
  6. Keywords:
  7. 4 aminobutyric acid ; Gabapentin ; Levodopa ; Disease ; Modeling ; Brain function ; Brain region ; Dose response ; Drug use ; Electrostimulation ; GABAergic system ; Long term care ; Parkinson disease ; Pathophysiology ; Prescription ; Priority journal ; Treatment planning ; Antiparkinson Agents ; Brain ; Deep Brain Stimulation ; Dopamine ; Dose-Response Relationship, Drug ; Drug Resistance ; Electrodes, Implanted ; Electromyography ; Hand ; Humans ; Models, Biological ; Treatment Outcome ; Tremor
  8. Source: Journal of Theoretical Biology ; Volume 236, Issue 3 , 2005 , Pages 311-322 ; 00225193 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/pii/S0022519305001232?via%3Dihub