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Solid lithium perchlorate as a powerful catalyst for the synthesis of β-aminoalcohols under solvent-free conditions

Azizi, N ; Sharif University of Technology | 2005

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  1. Type of Document: Article
  2. DOI: 10.1139/v05-062
  3. Publisher: 2005
  4. Abstract:
  5. Lithium perchlorate catalyzed the ring opening of epoxides with amines to provide the corresponding β-aminoalcohols in excellent yields with high regioselectivity. The reaction proceeds rapidly under mild and neutral conditions and worked well with primary, secondary, aliphatic, aromatic, and hindered amines in short times at room temperature, in the absence of solvent. © 2005 NRC Canada
  6. Keywords:
  7. Amines ; Aromatic compounds ; Catalysts ; Rings (components) ; Sodium compounds ; Solvents ; Synthesis (chemical) ; Aminoalcohols ; Epoxides ; Regioselectivity ; Sodium lithium perchlorates ; Alcohols ; Aliphatic amine ; Amine ; Aminoalcohol ; Aromatic amine ; Beta aminoalcohol ; Epoxide ; Lithium ; Lithium perchlorate ; Perchlorate ; Primary amine ; Secondary amine ; Solvent ; Unclassified drug ; Catalysis ; Catalyst ; Reaction time ; Ring opening ; Room temperature ; Solid ; Solvation ; Solvent free system ; Stereochemistry ; Synthesis ; Technique
  8. Source: Canadian Journal of Chemistry ; Volume 83, Issue 5 , 2005 , Pages 505-507 ; 00084042 (ISSN)
  9. URL: https://cdnsciencepub.com/doi/10.1139/v05-062