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An intriguing effect of lithium perchlorate dispersed on silica gel in the bromination of aromatic compounds by N-bromosuccinimide

Bagheri, M ; Sharif University of Technology | 2005

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  1. Type of Document: Article
  2. DOI: 10.1139/v05-001
  3. Publisher: 2005
  4. Abstract:
  5. A convenient and efficient procedure for electrophilic aromatic bromination has been developed by mixing of N-bromosuccinimide and an aromatic compound at room temperature on the surface of silica gel mixed with solid anhydrous LiClO4. All of the substrates examined underwent clean electrophilic aromatic bromination in reaction times of a few minutes to afford the corresponding bromoarenes under neutral conditions in excellent yield. In the case of thiophenol, no substitution reaction occurred, and the corresponding disulfide was obtained in excellent yield. © 2005 NRC Canada
  6. Keywords:
  7. Dispersions ; Mixing ; Phenols ; Reaction kinetics ; Silica gel ; Thermal effects ; Bromoarenes ; Disulfides ; Lithium perchlorate ; N-bromosuccinimide ; Lithium compounds ; Aromatic compound ; Bromine ; Disulfide ; Lithium ; Lithium perchlorate ; n bromosuccinimide ; Perchlorate ; Polycyclic aromatic hydrocarbon derivative ; Thiophenol ; Unclassified drug ; Bromination ; Chemical structure ; Proton nuclear magnetic resonance ; Reaction analysis ; Reaction time ; Room temperature ; Solid ; Substitution reaction
  8. Source: Canadian Journal of Chemistry ; Volume 83, Issue 2 , 2005 , Pages 146-149 ; 00084042 (ISSN)
  9. URL: https://cdnsciencepub.com/doi/10.1139/v05-001