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The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis

Narmashiri, A ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.neubiorev.2022.104792
  3. Publisher: Elsevier Ltd , 2022
  4. Abstract:
  5. Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase B (MAOB), which causes oxidative stress and destroys dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) and is widely used to create animal models of PD. However, to-date, a comprehensive analysis of the MPTP effects on various aspects of PD does not exist. Here, we provide a systematic review and meta-analysis on the MPTP effects on memory and motor functions by analyzing 51 studies on more than one thousand animals mainly including rats and mice. The results showed that in addition to motor functions such as coordination, balance and locomotor activity, MPTP significantly affects various mnemonic processes including spatial memory, working memory, recognition memory, and associative memory compared with the control group with some differences between systemic and intra-nigral injections on spatial memory, familiar object recognition, and anxiety-like behaviors. Nevertheless, our analysis failed to find systematic relationship between MPTP injection protocol parameters reported and the extent of the induced PD symptoms that can be a cause of concern for replicability of MPTP studies. © 2022 Elsevier Ltd
  6. Keywords:
  7. Memory ; Motor ; MPTP ; Parkinson's disease (PD) ; Rodent ; 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine ; Dopamine receptor stimulating agent ; Monoamine ; Pyrrolidine derivative ; Anxiety ; Associative memory ; Elevated plus maze test ; Experimental behavioral test ; Medline ; Meta analysis ; Morris water maze test ; Motor performance ; Nonhuman ; Open field test ; Passive avoidance test ; Recognition ; Review ; Scopus ; Spatial memory ; Substantia nigra pars compacta ; Systematic review ; Tail suspension test ; Web of Science ; Working memory ; Animal ; Disease model ; Mouse ; Rat ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Cognition ; Disease Models, Animal ; Mice ; Parkinson disease ; Pyrrolidines ; Rats ; Rodentia
  8. Source: Neuroscience and Biobehavioral Reviews ; Volume 140 , 2022 ; 01497634 (ISSN)
  9. URL: https://pubmed.ncbi.nlm.nih.gov/35872230