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A smart tri-layered nanofibrous hydrogel thin film with controlled release of dual drugs for chemo-thermal therapy of breast cancer

Asgari, S ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1016/j.jddst.2022.103702
  3. Publisher: Editions de Sante , 2022
  4. Abstract:
  5. A tri-layered nanofibrous hydrogel thin film with temperature sensitivity is introduced as a new controlled drug release system to treat breast cancer. A simultaneous heat generation with the tunable release of dual drugs is observed in response to visible light radiation. A tri-layered nanofibrous sheet was fabricated through sequential electrospinning the blends of Au@Chit@DOX-loaded poly(N-isopropylacrylamide-co-N-methylol acrylamide) (poly (NIPAAm-co-NMA)) and Curcumin-loaded poly (vinyl alcohol) (Cu-loaded PVA), where the Cu-loaded PVA nanofibers (NFs) are sandwiched between two layers of Au@Chit@DOX-loaded poly (NIPAAm-co-NMA) NFs. After thermal crosslinking of the tri-layered nanofibrous sheet, the nanofibrous hydrogel thin film is obtained. FTIR/ATR, UV–Vis, Photoluminescence, and PXRD analyses were used for characterizing. PVA NFs and poly (NIPAAm-co-NMA) NFs were observed in the average diameters of 358 and 212 nm, respectively, and Au@Chit@DOX nanoparticles (NPs) appeared as local thickening inside the NFs. The distribution of drugs was visualized with confocal images. The thermal stability up to 295 °C and tensile strength of 0.65 MPa with 99.36% elongation were reported for the nanofibrous hydrogel thin film. Unlike the fast release of drugs from the nanofibrous sheet, a controlled release of drugs was observed from the nanofibrous hydrogel thin film at 45 °C and under visible light radiation. 52% at 45 °C and 55% under light radiation were reported for the Cur release and 86% at 45 °C and 88% under light radiation were observed for the release of DOX within 18 h. The in vitro cell viability results under light radiation displayed a chemo-thermal therapy over breast cancer cells. © 2022 Elsevier B.V
  6. Keywords:
  7. Combination chemo-thermal therapy ; Controlled release ; Hydrogel thin film ; Temperature-sensitive ; Tri-layered nanofibers ; curcumin ; Doxorubicin ; Gold ; Hydrogel ; Nanofiber ; Poly(n isopropylacrylamide co n methylol acrylamide ; Polyvinyl alcohol ; Unclassified drug ; Animal cell ; Breast cancer ; Cell viability ; Controlled drug release ; Cross linking ; Electrospinning ; In vitro study ; Light ; Mouse ; Nonhuman ; Photoluminescence ; Temperature sensitivity ; Tensile strength ; Thermogenesis ; Thermostability
  8. Source: Journal of Drug Delivery Science and Technology ; Volume 76 , 2022 ; 17732247 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S177322472200613X