Electrocatalytic determination of sumatriptan on the surface of carbon-paste electrode modified with a composite of cobalt/Schiff-base complex and carbon nanotube

Amiri, M ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1016/j.bioelechem.2011.03.003
  3. Publisher: 2011
  4. Abstract:
  5. The electrochemical oxidation of sumatriptan on the surface of carbon paste electrode modified with multi-walled carbon nanotube and cobalt methyl-salophen complex is studied by using cyclic voltammetry and polarization studies. The results indicate that the drug is irreversibly oxidized in a one electron oxidation mechanism. It was found that the peak potential shifted negatively with increasing pH, confirms that H + participate in the oxidation process. The electrode is shown to be very effective for the detection of sumatriptan in the presence of other biological reductant compounds. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of sumatriptan, ascorbic acid and uric acid, which makes it suitable for the simultaneous detection of sumatriptan in the presence of these compounds in clinical and pharmaceutical preparations. It can be concluded that multi-walled carbon nanotube and Shiff base complex have synergic effect on electroacatalytic oxidation of sumatriptan. A linear range of 1-1000μM and detection limit of 0.3μM was obtained for sumatriptan from DPV measurements using this electrode in 0.1M acetate buffered solution of pH 5.0. The electrode has been applied successfully for the determination of sumatriptan in synthetic serum and commercial tablets
  6. Keywords:
  7. Ascorbic acid ; Cobalt Schiff base ; Uric acid ; Ascorbic acids ; Biological reductant ; Buffered solutions ; Carbon nanotube composite electrode ; Carbon paste electrode ; Detection limits ; Electrocatalytic ; Linear range ; Modified electrodes ; One-electron oxidation ; Oxidation process ; Peak potentials ; Pharmaceutical preparations ; Polarization study ; Shiff-base complex ; Simultaneous detection ; Synergic effects ; Voltammetric peak ; Chemical sensors ; Cobalt ; Cobalt compounds ; Cyclic voltammetry ; Electrochemical oxidation ; Functional groups ; Ketones ; Multiwalled carbon nanotubes (MWCN) ; Organic acids ; Electrochemical electrodes ; Acetic acid ; Buffer ; Carbon ; Carbon nanotube ; Nanocomposite ; Schiff base ; Sumatriptan ; Cyclic potentiometry ; Drug oxidation ; Electrode ; human ; pH ; pharmaceutics ; Electrochemistry ; Electrodes ; Hydrogen-Ion Concentration ; Limit of Detection ; Nanotubes, Carbon ; Oxidation-Reduction ; Polarography ; Potentiometry ; Schiff Bases ; Tablets
  8. Source: Bioelectrochemistry ; Volume 81, Issue 2 , 2011 , Pages 81-85 ; 15675394 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S1567539411000399