Loading...

Loading drug on nanostructured Ti6Al4V-HA for implant applications

Abbaspour, S ; Sharif University of Technology | 2018

1333 Viewed
  1. Type of Document: Article
  2. DOI: 10.5829/ije.2018.31.08b.01
  3. Publisher: Materials and Energy Research Center , 2018
  4. Abstract:
  5. Arrayed Ti6Al4V nanotubes (TNT) coated with hydroxyapatite (HA) were synthesized via electrochemical anodization method. Paracetamol was loaded onto TNT-HA electrode. Effects of anodization, nanotube formation and hydroxyapatite deposition on sorption and release of the drug were investigated. Saturation time of paracetamol on the anodized samples was 30% shorter than the hydroxyapatite-coated samples. Release behavior of the loaded drug was studied by (a) plunging the probe into phosphate buffered saline (PBS), (b) sampling the drug-loaded PBS at different times and (c) analyzing the solution via ultraviolet-visible (UV-vis) spectroscopy. Results showed that HA electrodes hold higher amounts of paracetamol than the anodized samples at longer times. Scanning electron microscopy (SEM), MTT assay, and nanoindentation tests were used to characterize the produced electrodes. © 2018 Materials and Energy Research Center. All rights reserved
  6. Keywords:
  7. Drug capacity ; Hydroxyapatite ; Paracetamol ; Titanium nanotubes ; Aluminum alloys ; Controlled drug delivery ; Drug products ; Electrodes ; Nanotubes ; Scanning electron microscopy ; Titanium alloys ; Yarn ; Drug release ; Electro-chemical anodization ; Hydroxyapatite depositions ; Nanoindentation tests ; Nanotube formation ; Phosphate-buffered salines ; Targeted drug delivery
  8. Source: International Journal of Engineering, Transactions B: Applications ; Volume 31, Issue 8 , 2018 , Pages 1159-1165 ; 1728144X (ISSN)
  9. URL: http://www.ije.ir/Vol31/No8/B/abstract-2855.html