Search for: diseases
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    A Wavelet-packet-based approach for breast cancer classification

    , Article Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS ; 2011 , Pages 5100-5103 ; 1557170X (ISSN) ; 9781424441211 (ISBN) Torabi, M ; Razavian, S. M. J ; Vaziri, R ; Vosoughi Vahdat, B ; Sharif University of Technology
    In this paper, a new approach for non-invasive diagnosis of breast diseases is tested on the region of the breast without undue influence from the background and medically unnecessary parts of the images. We applied Wavelet packet analysis on the two-dimensional histogram matrices of a large number of breast images to generate the filter banks, namely sub-images. Each of 1250 resulting sub-images are used for computation of 32 two-dimensional histogram matrices. Then informative statistical features (e.g. skewness and kurtosis) are extracted from each matrix. The independent features, using 5-fold cross-validation protocol, are considered as the input sets of supervised classification. We... 

    Investigation of wall shear stress related factors in realistic carotid bifurcation geometries and different flow conditions

    , Article Scientia Iranica ; Volume 17, Issue 5 B , 2010 , Pages 358-366 ; 10263098 (ISSN) Jamalian Ardakani, S. S ; Jafarnejad, M ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
    Cardiovascular diseases are one of the major causes of death in the world; atherosclerosis being one aspect. Carotid bifurcation is one of the sites that are vulnerable to this disease. Wall Shear Stress (WSS) is known to be responsible for the process of atherogenesis. In this study, we have simulated the blood flow for Newtonian and non-Newtonian, steady and unsteady, flow conditions in three idealistic and five realistic geometries. A risk factor has been presented based on the results of wall shear stress and, then, a relation was found between geometrical features and the wall shear stress risk factor. Our main conclusions are: 1) The non-Newtonian behavior of blood elevates the value... 

    Coronary artery disease detection using computational intelligence methods

    , Article Knowledge-Based Systems ; Volume 109 , 2016 , Pages 187-197 ; 09507051 (ISSN) Alizadehsani, R ; Zangooei, M. H ; Hosseini, M. J ; Habibi, J ; Khosravi, A ; Roshanzamir, M ; Khozeimeh, F ; Sarrafzadegan, N ; Nahavandi, S ; Sharif University of Technology
    Elsevier B.V 
    Nowadays, cardiovascular diseases are very common and are one of the main causes of death worldwide. One major type of such diseases is the coronary artery disease (CAD). The best and most accurate method for the diagnosis of CAD is angiography, which has significant complications and costs. Researchers are, therefore, seeking novel modalities for CAD diagnosis via data mining methods. To that end, several algorithms and datasets have been developed. However, a few studies have considered the stenosis of each major coronary artery separately. We attempted to achieve a high rate of accuracy in the diagnosis of the stenosis of each major coronary artery. Analytical methods were used to... 

    Graphene scaffolds in progressive nanotechnology/stem cell-based tissue engineering of the nervous system

    , Article Journal of Materials Chemistry B ; Volume 4, Issue 19 , 2016 , Pages 3169-3190 ; 20507518 (ISSN) Akhavan, O ; Sharif University of Technology
    Royal Society of Chemistry  2016
    Although graphene/stem cell-based tissue engineering has recently emerged and has promisingly and progressively been utilized for developing one of the most effective regenerative nanomedicines, it suffers from low differentiation efficiency, low hybridization after transplantation and lack of appropriate scaffolds required in implantations without any degrading in functionality of the cells. In fact, recent studies have demonstrated that the unique properties of graphene can successfully resolve all of these challenges. Among various stem cells, neural stem cells (NSCs) and their neural differentiation on graphene have attracted a lot of interest, because graphene-based neuronal tissue... 

    Functional brain networks in parkinson's disease

    , Article 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017, 30 November 2017 through 1 December 2017 ; 2018 ; 9781538636091 (ISBN) Akbari, S ; Fatemizadeh, E ; Reza Deevband, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2018
    Parkinson's disease (PD) is the second most common and progressive neurological disorder. Parkinson's signs are caused by dysfunction in PD patient's brain network. Newly, resting state functional magnetic resonance imaging has been utilized to assess the altered functional connectivity in PD patients. In this study, we investigated the properties of the brain network topology in 19 PD patients compared to 17 normal healthy group by means of graph theory. In addition, we used four different graph formation methods to explore linear and nonlinear relationships between fMRI signals. Each correlation measure created a weighted graph for each subject. Different graph characteristics have been... 

    Centrality-based epidemic control in complex social networks

    , Article Social Network Analysis and Mining ; Volume 10, Issue 1 , 2020 Doostmohammadian, M ; Rabiee, H. R ; Khan, U. A ; Sharif University of Technology
    Springer  2020
    Recent progress in the areas of network science and control has shown a significant promise in understanding and analyzing epidemic processes. A well-known model to study epidemics processes used by both control and epidemiological research communities is the susceptible–infected–susceptible (SIS) dynamics to model the spread of disease/viruses over contact networks of infected and susceptible individuals. The SIS model has two metastable equilibria: one is called the endemic equilibrium and the other is known as the disease-free or healthy-state equilibrium. Control theory provides the tools to design control actions (allocating curing or vaccination resources) in order to achieve and... 

    A decision support system for demand management in healthcare supply chains considering the epidemic outbreaks: A case study of coronavirus disease 2019 (COVID-19)

    , Article Transportation Research Part E: Logistics and Transportation Review ; Volume 138 , June , 2020 Govindan, K ; Mina, H ; Alavi, B ; Sharif University of Technology
    Elsevier Ltd  2020
    The disasters caused by epidemic outbreaks is different from other disasters due to two specific features: their long-term disruption and their increasing propagation. Not controlling such disasters brings about severe disruptions in the supply chains and communities and, thereby, irreparable losses will come into play. Coronavirus disease 2019 (COVID-19) is one of these disasters that has caused severe disruptions across the world and in many supply chains, particularly in the healthcare supply chain. Therefore, this paper, for the first time, develops a practical decision support system based on physicians' knowledge and fuzzy inference system (FIS) in order to help with the demand... 

    Potential effects of alginate–pectin biocomposite on the release of folic acid and their physicochemical characteristics

    , Article Journal of Food Science and Technology ; Volume 57, Issue 9 , March , 2020 , Pages 3363-3370 Kiaei Pour, P ; Alemzadeh, I ; Vaziri, A. S ; Beiroti, A ; Sharif University of Technology
    Springer  2020
    Potential effects of folates on the treatment of several human diseases like cognitive function, neural tube defects, coronary heart disease and certain kinds of cancers have been discovered. However, the stability of folic acid against adverse conditions is a great concern. The present study investigates various alginate (A)–pectin (P) gastrointestinal-resistant hydrogel to immobilize folic acid. This involves evaluating different compositions of alginate–pectin to achieve higher encapsulation efficiency and stability during simulated gastric (SG) and simulated intestinal (SI) conditions. Coated alginate hydrogels with pectin resulted significant (p < 0.05) better protection of folic acid... 

    A k-NN method for lung cancer prognosis with the use of a genetic algorithm for feature selection

    , Article Expert Systems with Applications ; Volume 164 , 2021 ; 09574174 (ISSN) Maleki, N ; Zeinali, Y ; Akhavan Niaki, S. T ; Sharif University of Technology
    Elsevier Ltd  2021
    Lung cancer is one of the most common diseases for human beings everywhere throughout the world. Early identification of this disease is the main conceivable approach to enhance the possibility of patients’ survival. In this paper, a k-Nearest-Neighbors technique, for which a genetic algorithm is applied for the efficient feature selection to reduce the dataset dimensions and enhance the classifier pace, is employed for diagnosing the stage of patients’ disease. To improve the accuracy of the proposed algorithm, the best value for k is determined using an experimental procedure. The implementation of the proposed approach on a lung cancer database reveals 100% accuracy. This implies that one... 

    Wolfram-like syndrome with bicuspid aortic valve due to a homozygous missense variant in CDK13

    , Article Journal of Human Genetics ; Volume 66, Issue 10 , 2021 , Pages 1009-1018 ; 14345161 (ISSN) Acharya, A ; Raza, S. I ; Anwar, M. Z ; Bharadwaj, T ; Liaqat, K ; Khokhar, M. A. S ; Everard, J. L ; Nasir, A ; Nickerson, D. A ; Bamshad, M. J ; Ansar, M ; Schrauwen, I ; Ahmad, W ; Leal, S. M ; University of Washington Center for Mendelian Genomics ; Sharif University of Technology
    Springer Nature  2021
    Background: Wolfram syndrome (WFS) is characterized by deafness, diabetes mellitus, and diabetes insipidus along with optic atrophy. WFS has an autosomal recessive mode of inheritance and is due to variants in WFS1 and CISD2. Methods: We evaluated the underlying molecular etiology of three affected members of a consanguineous family with hearing impairment, bicuspid aortic valve, diabetes mellitus and insipidus, clinodactyly, and gastrointestinal tract abnormalities via exome sequencing approach. We correlated clinical and imaging data with the genetic findings and their associated phenotypes. Results: We identified a homozygous missense variant p.(Asn1097Lys) in CDK13, a gene previously... 

    A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discovery

    , Article Chemical Biology and Drug Design ; Volume 100, Issue 5 , 2022 , Pages 699-721 ; 17470277 (ISSN) Maghsoudi, S ; Taghavi Shahraki, B ; Rameh, F ; Nazarabi, M ; Fatahi, Y ; Akhavan, O ; Rabiee, M ; Mostafavi, E ; Lima, E. C ; Saeb, M. R ; Rabiee, N ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time-consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches,... 

    A large dataset of white blood cells containing cell locations and types, along with segmented nuclei and cytoplasm

    , Article Scientific Reports ; Volume 12, Issue 1 , 2022 ; 20452322 (ISSN) Kouzehkanan, Z. M ; Saghari, S ; Tavakoli, S ; Rostami, P ; Abaszadeh, M ; Mirzadeh, F ; Satlsar, E. S ; Gheidishahran, M ; Gorgi, F ; Mohammadi, S ; Hosseini, R ; Sharif University of Technology
    Nature Research  2022
    Accurate and early detection of anomalies in peripheral white blood cells plays a crucial role in the evaluation of well-being in individuals and the diagnosis and prognosis of hematologic diseases. For example, some blood disorders and immune system-related diseases are diagnosed by the differential count of white blood cells, which is one of the common laboratory tests. Data is one of the most important ingredients in the development and testing of many commercial and successful automatic or semi-automatic systems. To this end, this study introduces a free access dataset of normal peripheral white blood cells called Raabin-WBC containing about 40,000 images of white blood cells and color... 

    Nanomaterials for photothermal and photodynamic cancer therapy

    , Article Applied Physics Reviews ; Volume 9, Issue 1 , 2022 ; 19319401 (ISSN) Nasseri, B ; Alizadeh, E ; Bani, F ; Davaran, S ; Akbarzadeh, A ; Rabiee, N ; Bahadori, A ; Ziaei, M ; Bagherzadeh, M ; Saeb, M. R ; Mozafari, M ; Hamblin, M. R ; Sharif University of Technology
    American Institute of Physics Inc  2022
    In recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and has become particularly emphasized. Currently, by the extraordinary development of nanomaterials in different fields of medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) by toxic heat generation and photodynamic therapy (PDT) by reactive oxygen species, are known as promising phototherapeutic techniques, which can overcome the limitations of conventional protocols. Moreover, nanomaterial-based PDT and PTT match the simultaneous immune therapy and increase the immune system stimulation resulting from the denaturation of... 

    Application Microarray Technology in Infectious Diseases

    , M.Sc. Thesis Sharif University of Technology Nazari Nodooshan, Khadijeh (Author) ; Mahdavi-Amiri, Nezameddin (Supervisor) ; Karami, Ali (Co-Advisor)
    DNA microarrays consist of DNA microscopic points that are attached to a solid surface such as glass, plastic or silicon chip and formed as an array. The fixed pieces of DNA are considered as searchers. In an experiment, we can use thousands of searchers. Therefore, any microarray consists of the same number of genetic tests as the experiment performed on all of them in parallel. Whit this ability, arrays have speeded up the biological investigations. Microarray technology can be seen as a continued development of southern blotting. However, the most important stage in this technology, analysis of data, requires reliable bioinformatics tools achieving high reliabilities. Infectious diseases,... 

    Preparation of Hemodialysis Membrane on the Basis of Polysulfone

    , M.Sc. Thesis Sharif University of Technology Sajjadi, Morteza (Author) ; Moosavi, Ali (Supervisor) ; Abd Khodaei, Mohammad Jafar (Supervisor)
    In Hemodialysis, membrane dialyser and commonly hollow fibers are used to treat patients who suffer from end stage renal failure. When blood flows into membrane, it loses uremic toxins such as urea and creatinine. On the other hand, some of the vital proteins of blood pass through the membrane or they are adsorbed on the membrane surface. The more hydrophilicity of the membrane, the less adsorption of proteins is. In this study, to achieve high hydrophilicity and low adsorption of proteins on the polysulfone membrane surface, the presence of hydrophilic nano-particles SBA-15 in membrane composition is investigated. The nano-particles with mass percentages 0.25%, 0.5 % and 1 % to one mass of... 

    Investigating the Effects of DBS on Brain Connectivity by Causal Inference in Parkinson’s Disease

    , M.Sc. Thesis Sharif University of Technology Ostad Mohammadi, Mohammad (Author) ; Rabiee, Hamid Reza (Supervisor)
    Parkinson’s disease (PD) is a progressive debilitating neurological disorder that causes motor and cognitive impairment. Administration of dopaminergic medication (Levodopa) has been reported to be effective in attenuating the excessive pathological synchronization in basal ganglia. However, long term levodopa therapy has its pitfalls. High frequency deep brain stimulation (DBS) has been suggested as an effective alternative for reducing motor symptoms in PD. In this method, distinct brain regions involved in the pathophysiology of the disease are stimulated electrically at high frequencies (i.e. at 130 Hz). While several studies have been carried out on the effects of DBS and its clinical... 

    Biosensor for Fast Detection (Based on Thyroid Hormones)

    , M.Sc. Thesis Sharif University of Technology Moradi, Farshid (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    Thyroid gland is one of the important internal organs of the body that is responsible for T3 and T4 hormones secretion. Concentration of these hormones directly influences growth of body, thus measurement concentration of thyroid hormones is one of the most common experiments all of the world, specially in our country that Hypothyroidism is common among people. Secretion of hormones in thyroid gland controlled by TSH (thyroid Stimulating Hormone) that released from Pituitary gland. TSH concentration is opposite of level of thyroid secretion. Because of interconnected relationship between these three hormones, measurement of each of them is so important. Many researches for developing... 

    An Analysis of a Mathematical Model Describing the Geographic Spread of Dengue Disease

    , M.Sc. Thesis Sharif University of Technology Hashemifar, Alireza (Author) ; Hesaraki, Mahmoud (Supervisor)
    We consider a system of nonlinear partial differential equations corresponding to a generalization of a mathematical model for geographical spreading of dengue disease. the mosquito population is divided into subpopulations: winged form (mature female mosquitoes) and aquatic form (comprising eggs, larvae and pupae); the human population is divided into the subpopulations:susceptible, infected and removed (or immune). On the other hand we allow higher spatial dimensions and also parameters depending on space and time. is last generalization is done to cope with possible abiotic effects as variations in temperature, humidity, wind velocity, carrier capacities, and so on; thus, the results... 

    Differences of the Brain’s Surprise Response Due to the Habituation Effect in Neurodegenerative Patients and Healthy People

    , M.Sc. Thesis Sharif University of Technology Hosseinpour Khaledian, Kamyab (Author) ; Karbalaei Aghajan, Hamid (Supervisor)
    The brain is constantly placed in stochastic environments. This leads to the brain developing a probabilistic model for the environment. However, sometimes unexpected events occur that lead to surprise and a need for updating the probabilistic model. It can be concluded from this argument that reduction in brian’s surprise is a sign of learning. On the other hand, a probability distribution obtained from a probabilistic model contains an amount of uncertainty. Reducing this uncertainty can also be considered a sign of learning. Surprise and uncertainty can be obtained from a probability distribution using information theory concepts. Another important issue in learning is habituation, which... 

    Spatial analysis and mapping of malaria risk in an endemic area, south of Iran: A GIS based decision making for planning of control

    , Article Acta Tropica ; Volume 122, Issue 1 , 2012 , Pages 132-137 ; 0001706X (ISSN) Hanafi Bojd, A. A ; Vatandoost, H ; Oshaghi, M. A ; Charrahy, Z ; Haghdoost, A. A ; Zamani, G ; Abedi, F ; Sedaghat, M. M ; Soltani, M ; Shahi, M ; Raeisi, A ; Sharif University of Technology
    Bashagard district is one of the important malaria endemic areas in southern Iran. From this region a total of 16,199 indigenous cases have been reported in recent years. The aim of this study was to determine the situation of the disease and provide the risk map for the area. ArcGIS9.2 was used for mapping spatial distribution of malaria incidence. Hot spots were obtained using evidence-based weighting method for transmission risk. Environmental factors including temperature, relative humidity, altitude, slope and distance to rivers were combined by weighted multi criteria evaluation for mapping malaria hazard area at the district level. Similarly, risk map was developed by overlaying...