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Preparation and investigation the release behaviour of wax microspheres loaded with salicylic acid

Gifani, A ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. DOI: 10.1080/02652040802413107
  3. Publisher: 2009
  4. Abstract:
  5. Salicylic acid-beeswax microspheres were prepared by melt dispersion technique. The effects of formulation parameters on the microscopic characteristic, drug loading and cumulative amount of released drug were investigated by experimental design. Results showed that all of the microparticles were spherical with porous surfaces. The average size of microspheres was 2448 m, the drug content was in the range of 2245 and the encapsulation efficiency was 4693. Drug loading was influenced by emulsification speed as a main factor. All the microspheres had a burst release initially. The emulsifier concentration did not have a significant effect on drug release. The release behaviour of microspheres conformed best to Korsmeyer-Peppas semi-empirical model and the release of SA from beeswax microspheres was Fickian (n < 0.45)
  6. Keywords:
  7. Beeswax ; Experimental design ; Microsphere ; Salicylic acid ; Sustained release ; Propolis ; Wax ; Article ; Dispersion ; Drug formulation ; Drug release ; Emulsion ; Microencapsulation ; Productivity ; Animals ; Anti-Infective Agents ; Bees ; Drug Carriers ; Drug Compounding ; Microspheres ; Particle Size ; Porosity ; Salicylic Acid ; Waxes
  8. Source: Journal of Microencapsulation ; Volume 26, Issue 6 , 2009 , Pages 485-492 ; 02652048 (ISSN)
  9. URL: https://www.ncbi.nlm.nih.gov/pubmed/18791907