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Poly(glycidyl methacrylate)-coated magnetic graphene oxide as a highly efficient nanocarrier: Preparation, characterization, and targeted DOX delivery

Pourjavadi, A ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1039/c9nj04623b
  3. Publisher: Royal Society of Chemistry , 2019
  4. Abstract:
  5. Herein, we report the preparation of novel magnetic graphene oxide (GO) grafted with brush polymer via surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization and its application as a nanocarrier for magnetic- and pH-triggered delivery of doxorubicin anticancer drug. The RAFT agent, DDMAT, was firstly attached to the surface of magnetic GO nanosheets. The DDMAT-functionalized magnetic GO nanosheets were then used to polymerize glycidyl methacrylate (GMA) using an SI-RAFT method. Afterwards, the epoxy rings of the PGMA chains were opened with hydrazine (N2H4) moieties. The resulting nanocomposite was used as a drug carrier for doxorubicin (DOX) as an anticancer drug. DOX molecules were covalently loaded onto the nanocarriers via imine coupling and π-π stacking. The in vitro drug release study of the prepared nanocarriers revealed that DOX can be released under an acidic medium indicating a pH-sensitive behavior. Also, the MTT cytotoxicity assay of the nanocarriers showed excellent biocompatibility. It can be envisioned that the synthesized magnetic nanocarriers could be regarded as a promising type of anticancer drug delivery system (DDS). This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique
  6. Keywords:
  7. Doxorubicin ; Graphene oxide ; Imine ; Nanocarrier ; Nanocomposite ; Nanosheet ; Poly(glycidyl methacrylate) ; Polymer ; Unclassified drug ; Biocompatibility ; Confocal laser scanning microscopy ; Controlled study ; Cytotoxicity assay ; Drug delivery system ; Drug release ; HeLa cell line ; Human ; Human cell ; Hydrodynamics ; In vitro study ; Photon correlation spectroscopy ; Polymerization ; Priority journal ; Ring opening ; Thermogravimetry ; X ray diffraction
  8. Source: New Journal of Chemistry ; Volume 43, Issue 47 , 2019 , Pages 18647-18656 ; 11440546 (ISSN)
  9. URL: https://pubs.rsc.org/en/content/articlelanding/2019/nj/c9nj04623b#!divAbstract