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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 56065 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Yaghmaei, Soheyla; Mashayekhan, Shohreh
- Abstract:
- "osteoarthritis" is one of the most common joint diseases. This disease has a close relationship with factors such as aging, weight gain, genetics, mechanical pressures, and severe injuries. Although the mechanism of this disease is not fully understood, inflammation is one of the main causes of its exacerbation and progression. controlling inflammation can greatly help in controlling the disease. One of the common treatment methods for osteoarthritis is intra-articular injection of hyaluronic acid and triamcinolone as anti-inflammatory drug. Hyaluronic acid is the main component of synovial fluid, with its viscosupplementation property, prevents bones from rubbing against each other in the joint. due to its short half-life in the presence of hyaluronidase enzyme in the joint, its therapeutic effects are short-term. In this project, our focus has been on reducing joint inflammation through a long-term drug delivery system to minimize the drug's side effects and enhance its anti-inflammatory and pain-reducing effects. Chitosan was used as a secondary polymer to form a hydrogel to improve the properties of hyaluronic acid and increase its residence time in the joint. Hyaluronic acid reacts with oxidized sodium hydride to create aldehyde groups on its chains and undergoes Schiff-base reaction with chitosan amine groups. The hydrogel gelation time is 30 seconds. Due to the very low solubility of triamcinolone in the hydrogel and its long-term release, beta-cyclodextrin was used as a carrier for loading the drug inside the hydrogel. The variable in this study was the molecular weight of hyaluronic acid (0.7, 7, 12 MDa), which was used to prepare three hydrogel samples (HA0.7, HA7, HA12). Degradability, drug release, antibacterial, and swelling analyses were performed to select the optimum sample. The HA12 sample, as the optimal sample, had a 30% drug release in 24 days
- Keywords:
- Drug Delivery ; Osteoarthritis ; In-Situ Forming Hydrogel ; Hyaluronic Acid Gel ; Chitosan ; Triamcinolone Drug ; Inflammation ; Arthritis Rheumatoid
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