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Catalyst-Free and Green Synthesis of Some Novel Benzamide Derivatives

Samani Ghaleh Taki, B ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1002/jhet.2275
  3. Publisher: HeteroCorporation , 2015
  4. Abstract:
  5. In the present work, a simple, green, rapid, and catalyst-free procedure for the synthesis of benzamide derivatives by ring opening of azlactones with diamines such as ethylene diamine and 1,3-propylenediamine is described. The present method offers several advantages such as short reaction times, easy work-up, and mild reaction conditions in the absence of catalyst and any toxic solvent and material. In addition, the structure obtained by X-ray crystallography was compared with the theoretical results obtained by density functional theory using the B3LYP functional and cc-pVDZ basis sets
  6. Keywords:
  7. 1,2 phenylenediamine ; 1,3 propanediamine ; Acetonitrile ; Alcohol ; Amide ; Benzamide derivative ; Copper ; Dimethyl sulfoxide ; Ethylenediamine ; Ferric ion ; Macrogol 400 ; Manganese ; Methanol ; Palladium ; Zinc ion ; Absorption spectroscopy ; Carbon nuclear magnetic resonance ; Chemical structure ; Conformation ; Crystal structure ; Density functional theory ; Hydrogen bond ; Proton nuclear magnetic resonance ; Reaction time ; Ring opening ; Room temperature ; Synthesis ; Ultraviolet spectroscopy ; X ray crystallography
  8. Source: Journal of Heterocyclic Chemistry ; Volume 52, Issue 6 , November , 2015 , Pages 1848-1857 ; 0022152X (ISSN)
  9. URL: http://onlinelibrary.wiley.com/doi/10.1002/jhet.2275/abstract