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Magnetic graphene oxide mesoporous silica hybrid nanoparticles with dendritic pH sensitive moieties coated by PEGylated alginate-co-poly (acrylic acid) for targeted and controlled drug delivery purposes

Pourjavadi, A ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1007/s10965-015-0799-y
  3. Publisher: Kluwer Academic Publishers , 2015
  4. Abstract:
  5. In this study synthesis of a drug delivery system (DDS) is described which has several merits over its counterparts. In order to synthesize this nano-carrier, graphene oxide nano-sheets are used to accommodate MCM-41 nanoparticles. Furthermore Fe3O4 nanoparticles are introduced to this nano-material to produce a traceable nanoparticle. Since cancerous tissues have lower pH than healthy tissues, pH-sensitive oligomers are attached to this nano-material. Finally the nano-carrier is wrapped by a biocompatible shell (PEGylated sodium alginate); this polymeric shell makes the DDS capable of a more controllable drug release. By measuring in vitro situation, ‘loading content%’ and ‘entrapment efficiency%’ proves to be 21 and 93.5 % respectively. In an acidic medium, the drug carrier without a polymeric shell (naked DDS) releases the whole of its drug content in 18 h, while the drug carrier with a polymeric shell (core-shell DDS) releases 45 % of its drug content during 48 h
  6. Keywords:
  7. Drug delivery systems ; MCM-41 mesoporous silica ; PEGylated sodium alginate ; pH-sensitive nanoparticles ; Acrylics ; Alginate ; Biocompatibility ; Drug products ; Graphene ; Histology ; Hydrogels ; Mesoporous materials ; Nanomagnetics ; Nanoparticles ; Nanosheets ; pH sensors ; Polymers ; Shells (structures) ; Silica ; Sodium ; Sodium alginate ; Synthesis (chemical) ; Tissue ; Drug delivery system ; Mcm-41 mesoporous silicas ; Pegylated ; pH sensitive ; Stimuli-sensitive polymers ; Controlled drug delivery
  8. Source: Journal of Polymer Research ; Volume 22, Issue 8 , 2015 ; 10229760 (ISSN)
  9. URL: http://link.springer.com/article/10.1007%2Fs10965-015-0799-y