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A sensitive colorimetric detection of ascorbic acid in pharmaceutical products based on formation of anisotropic silver nanoparticles

Hormozi Nezhad, M. R ; Sharif University of Technology | 2010

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  1. Type of Document: Article
  2. Publisher: 2010
  3. Abstract:
  4. A sensitive colorimetric method for the detection of ascorbic acid was proposed in this research based on the reduction of silver ions by ascorbic acid in the presence of citrate-stabilized silver seeds, additional trisodium citrate and a polymer such as polyvinylpyrrolidone. The color of the stable sol is controlled by varying the concentration of trisodium citrate (TSC), polyvinylpyrrolidone, silver nitrate and silver seeds. The reduction of Ag + to triangle silver nanoparticles (Ag-NPs) by ascorbic acid in the presence of trisodium citrate (TSC) and silver seeds produced two very intense surface plasmon resonance peaks of Ag-NPs. The plasmon absorbance of Ag-NPs allows the quantitative spectrophotometric detection of the ascorbic acid. The calibration curve derived from the changes in absorbance at λ = 427 nm was linear, with the concentration of ascorbic acid in the range of 6.0 × 10-6 to 8.0 × 10-5 M. The method was applied to the determination of ascorbic acid in pharmaceutical formulations with satisfactory results
  5. Keywords:
  6. Ascorbic acid ; Absorbances ; Ascorbic acids ; Calibration curves ; Colorimetric detection ; Colorimetric methods ; Pharmaceutical formulation ; Pharmaceutical products ; Plasmon absorbance ; Poly vinyl pyrrolidone ; Silver ions ; Silver nanoparticles ; Silver nitrates ; Spectrophotometric detection ; Surface plasmon band ; Surface plasmons ; Triangular silver nanoparticles ; Trisodium citrates ; Color ; Colorimetry ; Drug products ; Ketones ; Metal ions ; Nanoparticles ; Organic acids ; Plasmons ; Seed ; Surface plasmon resonance ; Colorimetry ; Drug ; Nanotechnology ; Polymer
  7. Source: Scientia Iranica ; Volume 17, Issue 2 F , 2010 , Pages 148-153 ; 10263098 (ISSN)
  8. URL: http://archive.scientiairanica.com/PDF/Articles/00001535/hormozinezhad.pdf