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Synthesis of novel polycyclic indole-annulated thiopyranocoumarin derivatives via domino Knoevenagel-hetero-Diels-Alder reaction in aqueous media

Matloubi Moghaddam, F ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1002/hlca.200900324
  3. Abstract:
  4. An efficient synthesis of polycyclic indole derivatives is achieved via domino Knoevenagel - hetero-Diels - Alder reaction of O-acrylated salicylaldehyde derivatives with dihydroindole-2-thiones in H2O as solvent. The products are formed in good-to-excellent yields with high regio- and stereoselectivity
  5. Keywords:
  6. Aqueous media ; Efficient synthesis ; Hetero-Diels-Alder reactions ; Indole derivatives ; Thiones ; Aldehydes ; Synthesis (chemical) ; Coumarin derivative ; Dihydroindole 2 thione ; Indole derivative ; Polycyclic indole ; Salicylaldehyde ; Solvent ; Thiopyranocoumarin derivative ; Tritium oxide ; Unclassified drug ; Aqueous solution ; Article ; Catalyst ; Chemical structure ; Diels Alder reaction ; Priority journal ; Stereochemistry ; Synthesis
  7. Source: Helvetica Chimica Acta ; Volume 93, Issue 5 , 2010 , Pages 964-973 ; 0018019X (ISSN)
  8. URL: http://onlinelibrary.wiley.com/doi/10.1002/hlca.200900324/abstract