Loading...

Folate-receptor-targeted delivery of doxorubicin using polyethylene glycol-functionalized gold nanoparticles

Asadishad, B ; Sharif University of Technology

1096 Viewed
  1. Type of Document: Article
  2. DOI: 10.1021/ie9011479
  3. Abstract:
  4. Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug release response of functionalized gold nanoparticles was characterized by an initial rapid drug release followed by a controlled release. The doxorubicin nanocarriers showed higher cytotoxic effect on folate-receptor-positive cells (KB cells) than folatereceptor-negative cells (A549 cells). Cell viability in healthy cells (HFF cells) in drug-loaded nanoparticles was higher compared to free doxorubicin. These nanocarriers might offer a cancer therapy with high targeting efficiency and lower side effects
  5. Keywords:
  6. Gold nanoparticles ; A549 cells ; Cancer cells ; Cancer therapy ; Cell viability ; Controlled release ; Cytotoxic effects ; Doxorubicin ; Drug release ; Functionalized ; Average size ; Nanocarriers ; Side effect ; Targeted delivery ; Cells ; Gold ; Nanoparticles ; Polyethylene oxides ; Thermoplastics ; Polyethylene glycols
  7. Source: Industrial and Engineering Chemistry Research ; Volume 49, Issue 4 , 2010 , Pages 1958-1963 ; 08885885 (ISSN)
  8. URL: http://pubs.acs.org/doi/abs/10.1021/ie9011479