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Measurement and modeling process partitioning of cephalexin antibiotic in aqueous two-phase systems containing poly(ethylene glycol) 4000, 10000 and K2HPO4, Na3Citrate

Khederlou, K ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. DOI: 10.1021/je800996j
  3. Publisher: 2009
  4. Abstract:
  5. In this work, the partition coefficients of Cephalexin in aqueous two-phase systems containing PEG [poly(ethylene glycol)] 4000, 10000 and K 2HPO4, Na3Citrate (C6H 5Na3O7 5, 5H2O) have been measured. The experimental data were obtained in a wide range of temperatures, (28.2 to 37.2) °C. The effects of temperature, pH, polymer concentration, polymer molecular weight, and salt concentration on the partitioning of Cephalexin were also studied. The results showed that salt concentration has a large effect on the partition coefficient, and temperature has an almost negligible effect. The Chen-NRTL Gibbs energy model was used to correlate the experimental results. © 2009 American Chemical Society
  6. Keywords:
  7. Aqueous two phase system ; Cephalexin ; Effects of temperature ; Experimental data ; Gibbs energy model ; Modeling process ; Partition coefficient ; Poly(ethylene glycol) ; Polymer concentrations ; Polymer molecular weight ; Salt concentration ; Ethylene ; Ethylene glycol ; Gibbs free energy ; Polyethylene glycols ; Polyethylene oxides ; pH effects
  8. Source: Journal of Chemical and Engineering Data ; Volume 54, Issue 8 , 2009 , Pages 2239-2244 ; 00219568 (ISSN)
  9. URL: https://pubs.acs.org/doi/abs/10.1021/je800996j