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A perspective to the correlation between brain insulin resistance and Alzheimer: Medicinal chemistry approach

Rabiee, N ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.2174/1573399814666181031154817
  3. Publisher: Bentham Science Publishers , 2019
  4. Abstract:
  5. Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable approach from the Medicinal Chemistry concepts. © 2019 Bentham Science Publishers
  6. Keywords:
  7. ADRDs ; Alzheimer ; Human post-mortem ; Medicinal chemistry ; Type 2 diabetes mellitus ; Insulin receptor ; Alzheimer disease and related dementia ; Article ; Autopsy ; Brain level ; Dementia ; Hormone action ; Human ; Insulin level ; Insulin signaling ; MRNA expression level ; Non insulin dependent diabetes mellitus ; Priority journal ; Protein expression level ; Metabolism ; Alzheimer Disease ; Brain ; Chemistry, Pharmaceutical ; Diabetes Mellitus, Type 2 ; Humans ; Insulin ; Insulin Resistance
  8. Source: Current Diabetes Reviews ; Volume 15, Issue 4 , 2019 , Pages 255-258 ; 15733998 (ISSN)
  9. URL: https://www.eurekaselect.com/166840/article