Loading...

Sustained release of CIP from TiO2-PVDF/starch nanocomposite mats with potential application in wound dressing

Ansarizadeh, M ; Sharif University of Technology | 2020

575 Viewed
  1. Type of Document: Article
  2. DOI: 10.1002/app.48916
  3. Publisher: John Wiley and Sons Inc , 2020
  4. Abstract:
  5. Electrospinning is an economical and alluring method to fabricate wound dressing mats from a variety of natural and synthetic materials. In this study, polyvinylidene fluoride (PVDF) and starch composite mats containing ciprofloxacin (CIP) loaded on titanium dioxide nanoparticles (TiO2) were prepared. Fourier Transform Infrared spectra of CIP, synthesized TiO2 NPs, TiO2/CIP, and PVDF/starch composite mats are analyzed. Scanning electron microscopy images revealed that the fiber diameter of PVDF nanofibers thickens by increasing starch, which varies between 180 nm and 550 nm. Strain at break of PVDF, starch, PVDF/starch (2:1 w:w; P2S1), PVDF/starch (1:1 w:w; P1S1), PVDF/starch (1:2 w:w; P1S2), and nanofibers were 103 ± 11, 3 ± 0.6, 27 ± 4, 52 ± 5.2, 7.7 ± 1%, respectively. Based on strain at break and young modulus, P2S1 was selected as a suitable candidate for wound dressing to which load TiO2/CIP as a bioactive agent. The release rate of CIP showed that about 40% of the drug is released in the first 2 days. Furthermore, the antibacterial activity of dressings was investigated using Escherichia coli and Staphylococcus aureus microorganisms and zones of clearance were obvious around the specimen on the agar plate. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48916. © 2020 Wiley Periodicals, Inc
  6. Keywords:
  7. Drug delivery systems ; Biomaterials ; Controlled drug delivery ; Escherichia coli ; Fibers ; Fluorine compounds ; Medical applications ; Nanofibers ; Rheology ; Scanning electron microscopy ; Starch ; Targeted drug delivery ; Titanium dioxide ; Anti-bacterial activity ; Biomedical applications ; Drug delivery system ; Fourier transform infrared spectra ; Polyvinylidene fluorides ; Scanning electron microscopy image ; Staphylococcus aureus ; Synthetic materials ; TiO2 nanoparticles
  8. Source: Journal of Applied Polymer Science ; Volume 137, Issue 30 , 2020
  9. URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/app.48916